Calvin H Jan
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Explore the profile of Calvin H Jan including associated specialties, affiliations and a list of published articles.
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17
Citations
2922
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Recent Articles
1.
Harris D, Jan C
Nucleic Acids Res
. 2025 Feb;
53(4).
PMID: 39970294
Genetic screens using CRISPR (Clustered Regularly Interspaced Palindromic Repeats) provide valuable information about gene function. Nearly all pooled screening technologies rely on the cell to link genotype to phenotype, making...
2.
Harris D, Jan C
Nucleic Acids Res
. 2025 Feb;
53(4).
PMID: 39921565
Genetic screens using CRISPR (Clustered Regularly Interspaced Palindromic Repeats) provide valuable information about gene function. Nearly all pooled screening technologies rely on the cell to link genotype to phenotype, making...
3.
Ramezani M, Weisbart E, Bauman J, Singh A, Yong J, Lozada M, et al.
Nat Methods
. 2025 Jan;
22(3):621-633.
PMID: 39870862
A key challenge of the modern genomics era is developing empirical data-driven representations of gene function. Here we present the first unbiased morphology-based genome-wide perturbation atlas in human cells, containing...
4.
Yong J, Villalta J, Vu N, Kukurugya M, Olsson N, Lopez M, et al.
Elife
. 2024 Dec;
12.
PMID: 39713930
Protein aggregation increases during aging and is a pathological hallmark of many age-related diseases. Protein homeostasis (proteostasis) depends on a core network of factors directly influencing protein production, folding, trafficking,...
5.
Ramezani M, Bauman J, Singh A, Weisbart E, Yong J, Lozada M, et al.
bioRxiv
. 2023 Aug;
PMID: 37609130
A key challenge of the modern genomics era is developing data-driven representations of gene function. Here, we present the first unbiased morphology-based genome-wide perturbation atlas in human cells, containing three...
6.
Monahan Vargas E, Matamoros A, Qiu J, Jan C, Wang Q, Gorczyca D, et al.
Genes Dev
. 2020 Jan;
34(3-4):194-208.
PMID: 31919191
Promoting axon regeneration in the central and peripheral nervous system is of clinical importance in neural injury and neurodegenerative diseases. Both pro- and antiregeneration factors are being identified. We previously...
7.
Pech M, Fong L, Villalta J, Chan L, Kharbanda S, OBrien J, et al.
Elife
. 2019 Aug;
8.
PMID: 31452512
Only a subset of cancer patients respond to T-cell checkpoint inhibitors, highlighting the need for alternative immunotherapeutics. We performed CRISPR-Cas9 screens in a leukemia cell line to identify perturbations that...
8.
Shurtleff M, Itzhak D, Hussmann J, Schirle Oakdale N, Costa E, Jonikas M, et al.
Elife
. 2018 May;
7.
PMID: 29809151
The endoplasmic reticulum (ER) supports biosynthesis of proteins with diverse transmembrane domain (TMD) lengths and hydrophobicity. Features in transmembrane domains such as charged residues in ion channels are often functionally...
9.
Friedman J, Kannan M, Toulmay A, Jan C, Weissman J, Prinz W, et al.
Dev Cell
. 2018 Jan;
44(2):261-270.e6.
PMID: 29290583
Spatial organization of phospholipid synthesis in eukaryotes is critical for cellular homeostasis. The synthesis of phosphatidylcholine (PC), the most abundant cellular phospholipid, occurs redundantly via the ER-localized Kennedy pathway and...
10.
Aviram N, Ast T, Costa E, Arakel E, Chuartzman S, Jan C, et al.
Nature
. 2016 Dec;
540(7631):134-138.
PMID: 27905431
In eukaryotes, up to one-third of cellular proteins are targeted to the endoplasmic reticulum, where they undergo folding, processing, sorting and trafficking to subsequent endomembrane compartments. Targeting to the endoplasmic...