C S Samuel
Overview
Explore the profile of C S Samuel including associated specialties, affiliations and a list of published articles.
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20
Citations
469
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Recent Articles
1.
McDonald H, Peart J, Kurniawan N, Galloway G, Royce S, Samuel C, et al.
Biomed Pharmacother
. 2020 May;
127:110165.
PMID: 32403043
Acute myocardial ischemia and reperfusion injury (IRI) underly the detrimental effects of coronary heart disease on the myocardium. Despite the ongoing advances in reperfusion therapies, there remains a lack of...
2.
Samuel C, Royce S, Hewitson T, Denton K, Cooney T, Bennett R
Br J Pharmacol
. 2016 Jun;
174(10):962-976.
PMID: 27250825
Linked Articles: This article is part of a themed section on Recent Progress in the Understanding of Relaxin Family Peptides and their Receptors. To view the other articles in this...
3.
Patel K, Giraud A, Samuel C, Royce S
Br J Pharmacol
. 2016 Apr;
173(12):2016-29.
PMID: 27060978
Background And Purpose: We evaluated the extent to which individual versus combination treatments that specifically target airway epithelial damage [trefoil factor-2 (TFF2)], airway fibrosis [serelaxin (RLX)] or airway inflammation [dexamethasone...
4.
Sarwar M, Samuel C, Bathgate R, Stewart D, Summers R
Br J Pharmacol
. 2015 Oct;
173(3):484-96.
PMID: 26493539
Background And Purpose: In the phase III clinical trial, RELAX-AHF, serelaxin caused rapid and long-lasting haemodynamic changes. However, the cellular mechanisms involved are unclear in humans. Experimental Approach: This study...
5.
Krishnan S, Dowling J, Ling Y, Diep H, Chan C, Ferens D, et al.
Br J Pharmacol
. 2015 Jun;
173(4):752-65.
PMID: 26103560
Background And Purpose: Inflammasomes are multimeric complexes that facilitate caspase-1-mediated processing of the pro-inflammatory cytokines IL-1β and IL-18. Clinical hypertension is associated with renal inflammation and elevated circulating levels of...
6.
Sobey C, Judkins C, Rivera J, Lewis C, Diep H, Lee H, et al.
Free Radic Res
. 2014 Dec;
49(2):186-98.
PMID: 25496431
Nicotinamide adenine dinucleotide phosphate oxidases (NOX) are enzymes that generate reactive oxygen species (ROS). NOX2 activity in the vascular wall is elevated in hypercholesterolemia, and contributes to oxidative stress and...
7.
Tilak M, Paul A, Samuel C, David J, Viswabandya A, Srivastava A
Haemophilia
. 2014 Dec;
21(1):e103-5.
PMID: 25471230
No abstract available.
8.
Sarwar M, Samuel C, Bathgate R, Stewart D, Summers R
Br J Pharmacol
. 2014 Oct;
172(4):1005-19.
PMID: 25297987
Background And Purpose: In a recently conducted phase III clinical trial, RELAX-AHF, serelaxin infusion over 48 h improved short- and long-term clinical outcomes in patients with acute heart failure. In...
9.
Royce S, Lim C, Patel K, Wang B, Samuel C, Tang M
Clin Exp Allergy
. 2014 Aug;
44(11):1399-408.
PMID: 25113628
Background: The peptide hormone relaxin plays a key role in the systemic hemodynamic and renovascular adaptive changes that occur during pregnancy, which is linked to its antiremodelling effects. Serelaxin (a...
10.
Yong K, Callander G, Bergin R, Samuel C, Bathgate R
Ital J Anat Embryol
. 2014 Mar;
118(1 Suppl):10-2.
PMID: 24640558
To study the specific actions of relaxin through RXFP1 in human cells, it would be advantageous to develop cell populations with permanent RXFP1 knockdown (KD). We have developed and assessed...