C G Sobey
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Explore the profile of C G Sobey including associated specialties, affiliations and a list of published articles.
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47
Citations
1057
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Recent Articles
1.
Krishnan S, Dowling J, Ling Y, Diep H, Chan C, Ferens D, et al.
Br J Pharmacol
. 2015 Jun;
173(4):752-65.
PMID: 26103560
Background And Purpose: Inflammasomes are multimeric complexes that facilitate caspase-1-mediated processing of the pro-inflammatory cytokines IL-1β and IL-18. Clinical hypertension is associated with renal inflammation and elevated circulating levels of...
2.
Sobey C, Judkins C, Rivera J, Lewis C, Diep H, Lee H, et al.
Free Radic Res
. 2014 Dec;
49(2):186-98.
PMID: 25496431
Nicotinamide adenine dinucleotide phosphate oxidases (NOX) are enzymes that generate reactive oxygen species (ROS). NOX2 activity in the vascular wall is elevated in hypercholesterolemia, and contributes to oxidative stress and...
3.
Krishnan S, Sobey C, Latz E, Mansell A, Drummond G
Br J Pharmacol
. 2014 Aug;
171(24):5589-602.
PMID: 25117218
Chronic inflammation in the kidneys and vascular wall is a major contributor to hypertension. However, the stimuli and cellular mechanisms responsible for such inflammatory responses remain poorly defined. Inflammasomes are...
4.
Fann D, Lee S, Manzanero S, Tang S, Gelderblom M, Chunduri P, et al.
Cell Death Dis
. 2013 Sep;
4:e790.
PMID: 24008734
Multi-protein complexes called inflammasomes have recently been identified and shown to contribute to cell death in tissue injury. Intravenous immunoglobulin (IVIg) is an FDA-approved therapeutic modality used for various inflammatory...
5.
Jackman K, Miller A, De Silva T, Crack P, Drummond G, Sobey C
Br J Pharmacol
. 2009 Jan;
156(4):680-8.
PMID: 19175604
Background And Purpose: Reactive oxygen species (ROS) derived from Nox2-containing reduced form of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity is reportedly detrimental in cerebrovascular disease. However, ROS generation by...
6.
Budzyn K, Ravi R, Miller A, Sobey C
Br J Pharmacol
. 2008 Jun;
155(2):210-6.
PMID: 18552867
Background And Purpose: To test whether development of enhanced vasoconstriction to 5-hydroxytryptamine (5-HT; serotonin) in SHR was temporally related to hypertension, elevated vascular superoxide (O(2)(-)) levels, decreased NO bioavailability, or...
7.
Sobey C, Faraci F
Curr Hypertens Rep
. 2001 Dec;
3(6):517-23.
PMID: 11734099
Chronic hypertension is a major risk factor for numerous cardiovascular disorders and is strongly associated with stroke. Hypertension alters cerebral vascular structure and may have profound deleterious effects on cerebral...
8.
Sobey C
Clin Exp Pharmacol Physiol
. 2001 Nov;
28(11):926-9.
PMID: 11703398
1. When a cerebral aneurysm ruptures, bleeding and clot formation occur around the surface of the brain, including several major blood vessels. The resulting condition, known as subarachnoid haemorrhage (SAH),...
9.
Faraci F, Sobey C, Chrissobolis S, Lund D, Heistad D, Weintraub N
Am J Physiol Regul Integr Comp Physiol
. 2001 Jun;
281(1):R246-53.
PMID: 11404300
Dilatation of cerebral arterioles in response to arachidonic acid is dependent on activity of cyclooxygenase. In this study, we examined mechanisms that mediate dilatation of the basilar artery in response...
10.
Chrissobolis S, Sobey C
Circ Res
. 2001 Apr;
88(8):774-9.
PMID: 11325868
The small G protein Rho and its target Rho-kinase may participate in the mechanisms underlying vascular contractile tone via inhibition of myosin light chain phosphatase. The present study has tested...