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C S Coleman

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Recent Articles
1.
Coleman C, Rocetes J, Park D, Wallick C, Warn-Cramer B, Michel K, et al.
Cell Prolif . 2006 Nov; 39(6):599-609. PMID: 17109642
Syringolin A is a new plant elicitor produced by the plant pathogen Pseudomonas syringae pv. syringae. The goal of this study was to investigate whether syringolin A exhibits anti-proliferative properties...
2.
Pegg A, Feith D, Fong L, Coleman C, OBrien T, Shantz L
Biochem Soc Trans . 2003 Mar; 31(2):356-60. PMID: 12653638
Transgenic mice expressing proteins altering polyamine levels in a tissue-specific manner have considerable promise for evaluation of the roles of polyamines in normal, hypertrophic and neoplastic growth. This short review...
3.
Coleman C, Pegg A
Biochem J . 2001 Aug; 358(Pt 1):137-45. PMID: 11485561
Spermidine/spermine N(1)-acetyltransferase (SSAT), a key enzyme in mammalian polyamine catabolism, undergoes rapid turnover (half-life approx. 30 min) and is highly inducible in response to polyamine analogues such as bis(ethyl)spermine (BE-3-4-3),...
4.
McCloskey D, Coleman C, Pegg A
J Biol Chem . 1999 Feb; 274(10):6175-82. PMID: 10037702
Spermidine/spermine N1-acetyltransferase (SSAT) appears to be the rate-limiting enzyme of polyamine catabolism, yet studies of its regulation have been limited by the low amounts of SSAT in uninduced cells. A...
5.
Mates J, del Valle A, Urdiales J, Coleman C, Feith D, Olmo M, et al.
Biochim Biophys Acta . 1998 Jul; 1386(1):113-20. PMID: 9675257
A well-conserved T/S cluster was detected among vertebrate ornithine decarboxylase by computer analysis (E. Viguera, O. Trelles, J.L. Urdiales, J.M. Matés, F. Sánchez-Jiménez, Trends Biochem. Sci. 19 (1994) 318-319). In...
6.
Coleman C, Pegg A
Methods Mol Biol . 1998 Feb; 79:41-4. PMID: 9463815
No abstract available.
7.
Coleman C, Pegg A
J Biol Chem . 1997 May; 272(18):12164-9. PMID: 9115288
The rapid turnover of spermidine/spermine N1-acetyltransferase (SSAT), a key enzyme in the regulation of polyamine levels, was found to be mediated via ubiquitination and the proteasomal system. SSAT degradation was...
8.
Engel N, Olmo M, Coleman C, Medina M, Pegg A, Sanchez-Jimenez F
Biochem J . 1996 Dec; 320 ( Pt 2):365-8. PMID: 8973541
Common protein motifs between histidine decarboxylase (HDC) and ornithine decarboxylase (ODC) were detected by computational analysis. Mutants were generated and expressed in vitro. In both enzymes, terminal PEST-region-containing fragments are...
9.
Shantz L, Coleman C, Pegg A
Cancer Res . 1996 Nov; 56(22):5136-40. PMID: 8912847
pMV7-4E cells (4E-P2), which overexpress translation initiation factor eIF-4E, contain elevated levels of ornithine decarboxylase (ODC), the first and rate-limiting enzyme in polyamine biosynthesis. We have shown previously that this...
10.
Coleman C, Huang H, Pegg A
Biochem J . 1996 Jun; 316 ( Pt 3):697-701. PMID: 8670140
Spermidine/spermine-N1-acetyltransferase (SSAT) is a key enzyme in the degradation of polyamines. Alanine-scanning mutagenesis of all eight arginine residues was used to investigate the arginine residues involved in acetyl-CoA binding. The...