C R Roman
Overview
Explore the profile of C R Roman including associated specialties, affiliations and a list of published articles.
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15
Citations
65
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Recent Articles
1.
ONeill M, Murray T, McCarty D, Hicks C, Dell C, Patrick K, et al.
Brain Res
. 2000 Jul;
871(2):234-44.
PMID: 10899290
In the present studies, we have evaluated the effects of N-[4-(2-¿[(3-Chlorophenyl)methyl]amino¿ethyl)phenyl]-2-thiophenecarbo ximidamide dihydrochloride (ARL 17477) on recombinant human neuronal NOS (nNOS) and endothelial NOS (eNOS). We then carried out pharmacokinetic...
2.
Snyder D, Bach N, DILLARD R, Draheim S, Carlson D, Fox N, et al.
J Pharmacol Exp Ther
. 1999 Feb;
288(3):1117-24.
PMID: 10027849
LY315920 is a potent, selective inhibitor of recombinant human, group IIA, nonpancreatic secretory PLA2 (sPLA2). In a chromogenic isolated enzyme assay, LY315920 inhibited sPLA2 activity with an IC50 of 9...
3.
Jackson W, Froelich L, Boyd R, Schrementi J, Saussy Jr D, Schultz R, et al.
J Pharmacol Exp Ther
. 1998 Dec;
288(1):286-94.
PMID: 9862783
The in vitro actions were investigated of LY293111, a potent and selective leukotriene B4 (LTB4) receptor antagonist, on human neutrophils, human blood fractions, guinea pig lung membranes, and guinea pig...
4.
Sofia M, Floreancig P, Bach N, Baker S, Nelson K, Sawyer J, et al.
Adv Exp Med Biol
. 1997 Jan;
400A:381-6.
PMID: 9547580
No abstract available.
5.
Fleisch J, Armstrong C, Roman C, Mihelich E, Spaethe S, Jackson W, et al.
J Pharmacol Exp Ther
. 1996 Jul;
278(1):252-7.
PMID: 8764358
The primary objective of this study was to develop a functional assay that could provide rapid and reliable information on some pharmacologic characteristics of a novel inhibitor of human secretory...
6.
Wong W, Roman C, Fleisch J
J Pharm Pharmacol
. 1995 Sep;
47(9):757-61.
PMID: 8583389
The biochemical mechanism subserving smooth muscle relaxant effects of sodium nitroprusside was examined on U46619, 9,11-dideoxy-9 alpha,11 alpha-methanoepoxy PGF2 alpha, precontracted guinea-pig lung strips and hilar bronchial rings. Lung strips...
7.
Sofia M, Floreancig P, Bach N, Baker S, Cockerham S, Fleisch J, et al.
J Med Chem
. 1993 Nov;
36(24):3978-81.
PMID: 7902871
No abstract available.
8.
Rinkema L, Roman C, VanAlstyne E, Spaethe S, Fleisch J
Naunyn Schmiedebergs Arch Pharmacol
. 1993 Nov;
348(5):520-5.
PMID: 8114952
Guinea pig inferior vena cava contracted in response to leukotriene (LT)C4, LTD4, LTE4 U46619, phenylephrine, histamine, and KCl. Although LTC4, LTD4, and U46619 were the most potent agonists, active tension...
9.
Silbaugh S, Stengel P, Cockerham S, Roman C, Saussy Jr D, Spaethe S, et al.
Eur J Pharmacol
. 1992 Nov;
223(1):57-64.
PMID: 1335877
The actions of LY255283, a leukotriene (LT) B4 receptor antagonist, were examined on guinea pig lung. LTB4 and LY255283 displaced [3H]LTB4 from its binding site on lung membranes with pKi...
10.
Sawyer J, Baldwin R, Rinkema L, Roman C, Fleisch J
J Med Chem
. 1992 Apr;
35(7):1200-9.
PMID: 1313877
This report describes the development of a series of highly potent quinoline-based leukotriene D4 (LTD4) receptor antagonists containing an N-benzyl-substituted phenyltetrazole moiety. They were designed to provide both the correct...