C P Redfern
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Explore the profile of C P Redfern including associated specialties, affiliations and a list of published articles.
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57
Citations
317
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Recent Articles
1.
Rana B, Pearson A, Redfern C
FEBS Lett
. 2001 Oct;
506(1):39-44.
PMID: 11591367
RXR beta is predominantly involved in retinoid responses in neuroblastoma cells, in particular the N-type SH SY 5Y cells and the S-type SH S EP cells, both derivatives of a...
2.
Lovat P, Dobson M, Malcolm A, Pearson A, Redfern C
Med Pediatr Oncol
. 2001 Jul;
36(1):135-8.
PMID: 11464866
Background: 9-cis retinoic acid (RA) is more effective than all-trans RA at inducing neuroblastoma differentiation in vitro, and has distinct biological properties with respect to its ability to promote apoptosis...
3.
Ponthan F, Borgstrom P, Hassan M, Wassberg E, Redfern C, Kogner P
Med Pediatr Oncol
. 2001 Jul;
36(1):127-31.
PMID: 11464864
Background: Neuroblastoma, a childhood tumour of the sympathetic nervous system, may undergo spontaneous differentiation or regression due to apoptosis after no or minimal therapy. However, the majority of neuroblastomas are...
4.
Annicchiarico-Petruzzelli M, Bernassola F, Lovat P, Redfern C, Pearson A, Melino G
Med Pediatr Oncol
. 2001 Jul;
36(1):115-7.
PMID: 11464861
Background And Procedure: The CD95/CD95 ligand (CD95L) system is a key regulator of apoptosis. To evaluate a possible role of the CD95/CD95L system in human neuroblastoma (NB) cells, we investigated...
5.
Dobson M, Redfern C, Unwin N, Weaver J
J Clin Endocrinol Metab
. 2001 May;
86(5):2270-4.
PMID: 11344238
Considerable evidence suggests that diabetes mellitus and hypertension are influenced by genetic factors. Studies in humans have associated glucocorticoid receptor (GR) polymorphisms with high blood pressure, insulin sensitivity, body mass...
6.
Bailey S, Hall A, Pearson A, Redfern C
Leukemia
. 2001 Mar;
15(3):391-7.
PMID: 11237062
Glucocorticoids are used in the treatment of acute lymphoblastic leukaemia (ALL) and chronic lymphocytic leukaemia (CLL) but many patients develop glucocorticoid resistance on relapse. The ligand-activated glucocorticoid receptor inhibits activity...
7.
Lovat P, Ranalli M, Bernassola F, Tilby M, Malcolm A, Pearson A, et al.
Med Pediatr Oncol
. 2000 Dec;
35(6):663-8.
PMID: 11107142
The RARbeta/gamma-selective retinoids fenretinide and CD437 induce caspase-dependent apoptosis but generate free radicals independently of caspases. Apoptosis, but not free radical generation, induced by these retinoids is inhibited by RARbeta/gamma-specific...
8.
Lovat P, Ranalli M, Bernassola F, Tilby M, Malcolm A, Pearson A, et al.
Int J Cancer
. 2000 Nov;
88(6):977-85.
PMID: 11093824
Retinoic acid therapy improves the survival of children with neuroblastoma and 13-cis retinoic acid now forms an important component of treatment for residual disease of stage IV neuroblastoma after chemotherapy....
9.
Lovat P, Ranalli M, Bernassola F, Piacentini M, Malcolm A, Pearson A, et al.
Exp Cell Res
. 2000 Sep;
260(1):50-60.
PMID: 11010810
Fenretinide is an effective inducer of apoptosis in many malignancies but its precise mechanism(s) of action in the induction of apoptosis in neuroblastoma is unclear. To characterize fenretinide-induced apoptosis, neuroblastoma...
10.
Hewson Q, Lova P, Malcolm A, Pearson A, Redfern C
Neurosci Lett
. 2000 Feb;
279(2):113-6.
PMID: 10674634
The aim of this study was to clarify retinoid receptor mechanisms mediating the effects of 9-cis retinoic acid (RA) and investigate the ability of RAR- and RXR-specific analogues to induce...