C Lawrence Kien
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Explore the profile of C Lawrence Kien including associated specialties, affiliations and a list of published articles.
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30
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679
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Recent Articles
11.
Koves T, Sparks L, Kovalik J, Mosedale M, Arumugam R, DeBalsi K, et al.
J Lipid Res
. 2012 Nov;
54(2):522-34.
PMID: 23175776
Intramuscular accumulation of triacylglycerol, in the form of lipid droplets (LD), has gained widespread attention as a hallmark of metabolic disease and insulin resistance. Paradoxically, LDs also amass in muscles...
12.
Kovalik J, Slentz D, Stevens R, Kraus W, Houmard J, Nicoll J, et al.
Diabetes
. 2011 May;
60(7):1882-93.
PMID: 21602515
Objective: Adipocyte infiltration of the musculoskeletal system is well recognized as a hallmark of aging, obesity, and type 2 diabetes. Intermuscular adipocytes might serve as a benign storage site for...
13.
Kien C, Everingham K, Stevens R, Fukagawa N, Muoio D
Obesity (Silver Spring)
. 2010 Jun;
19(2):305-11.
PMID: 20559306
In cultured cells, palmitic acid (PA) and oleic acid (OA) confer distinct metabolic effects, yet, unclear, is whether changes in dietary fat intake impact cellular fatty acid (FA) composition. We...
14.
Kien C, Blauwiekel R
JPEN J Parenter Enteral Nutr
. 2008 Jul;
32(4):439-42.
PMID: 18596316
Background: Cecal or distal colonic concentration of butyrate has been used as an index of butyrate production from various fermentable carbohydrates. However, we previously found that cecal concentration of butyrate...
15.
Kien C, Bunn J
Obesity (Silver Spring)
. 2008 Jan;
16(1):29-33.
PMID: 18223608
Objective: Because estrogen and testosterone affect transcription factors regulating mitochondrial function, we assessed the effects of gender on the metabolic response to dietary palmitic acid (PA) vs. oleic acid (OA)...
16.
Kien C, Peltier C, Mandal S, Davie J, Blauwiekel R
JPEN J Parenter Enteral Nutr
. 2008 Jan;
32(1):51-6.
PMID: 18165447
Background: In vitro, butyrate inhibits histone deacetylase and down-regulates expression of cyclin D1. We hypothesized that an increased entry rate of butyrate into the cecal lumen would have similar effects...
17.
Kien C, Bunn J
Obesity (Silver Spring)
. 2007 Jul;
15(7):1640-2.
PMID: 17636080
Objective: Using tracers, we showed, over 9 hours, that palmitic acid (PA) is oxidized at a lower rate than oleic acid (OA). Our subsequent clinical trial showed that enriching the...
18.
Kien C, Blauwiekel R, Williams C, Bunn J, Buddington R
JPEN J Parenter Enteral Nutr
. 2007 Apr;
31(3):194-8.
PMID: 17463144
Background: In order to understand the consequences of persistent enteral feeding in patients with carbohydrate malabsorption, we fed piglets lactulose in sufficient dosage to produce osmotic diarrhea or inulin, using...
19.
Kien C, Blauwiekel R, Bunn J, Jetton T, Frankel W, Holst J
J Nutr
. 2007 Mar;
137(4):916-22.
PMID: 17374654
The effects of colon-derived butyrate on intestinal cell proliferation are controversial. In vitro studies suggest an inhibitory effect, and in vivo studies suggest the opposite, but neither type of study...
20.
Borsheim E, Kien C, Pearl W
Metabolism
. 2006 Aug;
55(9):1215-21.
PMID: 16919541
Our previous studies suggest that diets varying in palmitic acid (PA) and oleic acid (OA) content may affect energy expenditure and fat oxidation differentially. We hypothesized that, compared with a...