C L Sommers
Overview
Explore the profile of C L Sommers including associated specialties, affiliations and a list of published articles.
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Articles
28
Citations
1371
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Recent Articles
1.
Rodriguez-Pena A, Gomez-Rodriguez J, Kortum R, Palmer D, Yu Z, Guittard G, et al.
Gene Ther
. 2015 May;
22(10):781-92.
PMID: 26018935
Linker for activation of T cells (LAT) is critical for the propagation of T-cell signals upon T-cell receptor (TCR) activation. Previous studies demonstrated that substitution of LAT lysines with arginines...
2.
Sommers C, Menon R, Grinberg A, Zhang W, Samelson L, Love P
J Exp Med
. 2001 Jul;
194(2):135-42.
PMID: 11457888
The integral membrane adapter protein linker for activation of T cells (LAT) performs a critical function in T cell antigen receptor (TCR) signal transduction by coupling the TCR to downstream...
3.
Azzam H, DeJarnette J, Huang K, Emmons R, Park C, Sommers C, et al.
J Immunol
. 2001 Apr;
166(9):5464-72.
PMID: 11313384
Current data indicate that CD5 functions as an inhibitor of TCR signal transduction. Consistent with this role, thymocyte selection in TCR transgenic/CD5(-/-) mice is altered in a manner suggestive of...
4.
Sommers C, DeJarnette J, Huang K, Lee J, Shores E, Love P
J Exp Med
. 2000 Sep;
192(6):913-19.
PMID: 10993922
The T cell antigen receptor (TCR) and pre-TCR complexes are composed of multiple signal-transducing subunits (CD3 gamma, CD3 delta, CD3 epsilon, and zeta) that each contain one or more copies...
5.
Saitoh S, Arudchandran R, Manetz T, Zhang W, Sommers C, Love P, et al.
Immunity
. 2000 Jun;
12(5):525-35.
PMID: 10843385
The linker molecule LAT is a substrate of the tyrosine kinases activated following TCR engagement of T cells. LAT is also expressed in platelets, NK, and mast cells. Although LAT-deficient...
6.
Rajagopal K, Sommers C, Decker D, Mitchell E, Korthauer U, Sperling A, et al.
J Exp Med
. 1999 Dec;
190(11):1657-68.
PMID: 10587356
A novel T cell-specific adaptor protein, RIBP, was identified based on its ability to bind Rlk/Txk in a yeast two-hybrid screen of a mouse T cell lymphoma library. RIBP was...
7.
Pasquet J, Gross B, Quek L, Asazuma N, Zhang W, Sommers C, et al.
Mol Cell Biol
. 1999 Nov;
19(12):8326-34.
PMID: 10567557
In the present study, we have addressed the role of the linker for activation of T cells (LAT) in the regulation of phospholipase Cgamma2 (PLCgamma2) by the platelet collagen receptor...
8.
Sommers C, Rabin R, Grinberg A, Tsay H, Farber J, Love P
J Exp Med
. 1999 Nov;
190(10):1427-38.
PMID: 10562318
Recent data indicate that several members of the Tec family of protein tyrosine kinases function in antigen receptor signal transduction. Txk, a Tec family protein tyrosine kinase, is expressed in...
9.
Zhang W, Sommers C, Burshtyn D, Stebbins C, DeJarnette J, Trible R, et al.
Immunity
. 1999 Apr;
10(3):323-32.
PMID: 10204488
The linker molecule LAT is a substrate of the tyrosine kinases activated following TCR engagement. Phosphorylated LAT binds many critical signaling molecules. The central role of this molecule in TCR-mediated...
10.
DeJarnette J, Sommers C, Huang K, Woodside K, Emmons R, Katz K, et al.
Proc Natl Acad Sci U S A
. 1998 Dec;
95(25):14909-14.
PMID: 9843989
T cell antigen receptor (TCR) and pre-TCR complexes are composed of clonotypic heterodimers in association with dimers of signal transducing invariant subunits (CD3gamma, -delta, -epsilon, and zeta). The role of...