C J Cambier
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Explore the profile of C J Cambier including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
950
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Recent Articles
1.
Guzman L, Cambier C, Cheng T, Naqvi K, Shiloh M, Moody D, et al.
ACS Chem Biol
. 2024 Mar;
19(3):707-717.
PMID: 38442242
Surface lipids on pathogenic mycobacteria modulate infection outcomes by regulating host immune responses. Phenolic glycolipid (PGL) is a host-modulating surface lipid that varies among clinical strains. PGL is also found...
2.
Kamariza M, Keyser S, Utz A, Knapp B, Ealand C, Ahn G, et al.
JACS Au
. 2021 Oct;
1(9):1368-1379.
PMID: 34604847
There is an urgent need for point-of-care tuberculosis (TB) diagnostic methods that are fast, inexpensive, and operationally simple. Here, we report on a bright solvatochromic dye trehalose conjugate that specifically...
3.
Cambier C, Banik S, Buonomo J, Bertozzi C
Elife
. 2020 Nov;
9.
PMID: 33226343
Several virulence lipids populate the outer cell wall of pathogenic mycobacteria. Phthiocerol dimycocerosate (PDIM), one of the most abundant outer membrane lipids, plays important roles in both defending against host...
4.
Walton E, Cronan M, Cambier C, Rossi A, Marass M, Foglia M, et al.
Cell Host Microbe
. 2018 Oct;
24(4):514-525.e6.
PMID: 30308157
Mycobacterial infection leads to the formation of characteristic immune aggregates called granulomas, a process accompanied by dramatic remodeling of the host vasculature. As granuloma angiogenesis favors the infecting mycobacteria, it...
5.
Cambier C, OLeary S, OSullivan M, Keane J, Ramakrishnan L
Immunity
. 2017 Aug;
47(3):552-565.e4.
PMID: 28844797
Mycobacterium tuberculosis (Mtb) enters the host in aerosol droplets deposited in lung alveoli, where the bacteria first encounter lung-resident alveolar macrophages. We studied the earliest mycobacterium-macrophage interactions in the optically...
6.
Madigan C, Cambier C, Kelly-Scumpia K, Scumpia P, Cheng T, Zailaa J, et al.
Cell
. 2017 Aug;
170(5):973-985.e10.
PMID: 28841420
Mycobacterium leprae causes leprosy and is unique among mycobacterial diseases in producing peripheral neuropathy. This debilitating morbidity is attributed to axon demyelination resulting from direct interaction of the M. leprae-specific...
7.
Berg R, Levitte S, OSullivan M, OLeary S, Cambier C, Cameron J, et al.
Cell
. 2016 Mar;
165(1):139-152.
PMID: 27015311
A zebrafish genetic screen for determinants of susceptibility to Mycobacterium marinum identified a hypersusceptible mutant deficient in lysosomal cysteine cathepsins that manifests hallmarks of human lysosomal storage diseases. Under homeostatic...
8.
Moguche A, Shafiani S, Clemons C, Larson R, Dinh C, Higdon L, et al.
J Exp Med
. 2015 Apr;
212(5):715-28.
PMID: 25918344
Immune control of persistent infection with Mycobacterium tuberculosis (Mtb) requires a sustained pathogen-specific CD4 T cell response; however, the molecular pathways governing the generation and maintenance of Mtb protective CD4...
9.
Cambier C, Falkow S, Ramakrishnan L
Cell
. 2014 Dec;
159(7):1497-509.
PMID: 25525872
Tuberculosis, an ancient disease of mankind, remains one of the major infectious causes of human death. We examine newly discovered facets of tuberculosis pathogenesis and explore the evolution of its...
10.
Cambier C, Takaki K, Larson R, Hernandez R, Tobin D, Urdahl K, et al.
Nature
. 2013 Dec;
505(7482):218-22.
PMID: 24336213
The evolutionary survival of Mycobacterium tuberculosis, the cause of human tuberculosis, depends on its ability to invade the host, replicate, and transmit infection. At its initial peripheral infection site in...