C Grubmeyer
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Explore the profile of C Grubmeyer including associated specialties, affiliations and a list of published articles.
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44
Citations
1020
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Recent Articles
1.
Wang F, Shi W, Nieves E, Angeletti R, Schramm V, Grubmeyer C
Biochemistry
. 2001 Jul;
40(27):8043-54.
PMID: 11434773
Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) is the key enzyme in purine base salvage in humans and in purine auxotrophs, including Plasmodium falciparum, the leading cause of malaria. Hydrogen/deuterium (H/D) exchange into amide...
2.
Shi W, Munagala N, Wang C, Li C, Tyler P, Furneaux R, et al.
Biochemistry
. 2000 Jun;
39(23):6781-90.
PMID: 10841757
Giardia lamblia, the protozoan parasite responsible for giardiasis, requires purine salvage from its host for RNA and DNA synthesis. G. lamblia expresses an unusual purine phosphoribosyltransferase with a high specificity...
3.
Smith J, Brachmann C, Celic I, Kenna M, Muhammad S, Starai V, et al.
Proc Natl Acad Sci U S A
. 2000 Jun;
97(12):6658-63.
PMID: 10841563
The yeast Sir2 protein, required for transcriptional silencing, has an NAD(+)-dependent histone deacetylase (HDA) activity. Yeast extracts contain a NAD(+)-dependent HDA activity that is eliminated in a yeast strain from...
4.
Shi W, Li C, Tyler P, Furneaux R, Cahill S, Girvin M, et al.
Biochemistry
. 1999 Aug;
38(31):9872-80.
PMID: 10433693
Malaria is a leading cause of worldwide mortality from infectious disease. Plasmodium falciparum proliferation in human erythrocytes requires purine salvage by hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRTase). The enzyme is a target for...
5.
Shi W, Li C, Tyler P, Furneaux R, Grubmeyer C, Schramm V, et al.
Nat Struct Biol
. 1999 Jun;
6(6):588-93.
PMID: 10360366
The structure of human HGPRT bound to the transition-state analog immucillinGP and Mg2+-pyrophosphate has been determined to 2.0 A resolution. ImmucillinGP was designed as a stable analog with the stereoelectronic...
6.
Li C, Tyler P, Furneaux R, Kicska G, Xu Y, Grubmeyer C, et al.
Nat Struct Biol
. 1999 Jun;
6(6):582-7.
PMID: 10360365
The proposed transition state for hypoxanthine-guanine phosphoribosyltransferases (HGPRTs) has been used to design and synthesize powerful inhibitors that contain features of the transition state. The iminoribitols (1S)-1-(9-deazahypoxanthin-9-yl)-1,4-dideoxy-1,4-imino-D-ribitol 5-phosphate (immucillinHP) and...
7.
Teng H, Grubmeyer C
Biochemistry
. 1999 Jun;
38(22):7363-71.
PMID: 10353848
The dimeric zinc metalloenzyme L-histidinol dehydrogenase (HDH) catalyzes an unusual four-electron oxidation of the amino alcohol histidinol via the histidinaldehyde intermediate to the acid product histidine with the reduction of...
8.
Grubmeyer C, Teng H
Biochemistry
. 1999 Jun;
38(22):7355-62.
PMID: 10353847
L-Histidinol dehydrogenase catalyzes the biosynthetic oxidation of L-histidinol to L-histidine with sequential reduction of two molecules of NAD. Previous isotope exchange results had suggested that the oxidation of histidinol to...
9.
Wang G, Cahill S, Liu X, Girvin M, Grubmeyer C
Biochemistry
. 1999 Jan;
38(1):284-95.
PMID: 9890909
In de novo pyrimidine biosynthesis, orotate phosphoribosyltransferase catalyzes the formation of orotidine 5'-monophosphate (OMP) from orotic acid and alpha-D-5-phosphoribosyl-1-pyrophosphate (PRPP). The known three-dimensional structure of the dimeric enzyme from Salmonella...
10.
Wang G, Lundegaard C, Jensen K, Grubmeyer C
Biochemistry
. 1999 Jan;
38(1):275-83.
PMID: 9890908
Orotate phosphoribosyltransferase (OMP synthase, EC 2.4.2.10) forms the UMP precursor orotidine 5'-monophophate (OMP) from orotate and alpha-D-5-phosphoribosyl-1-pyrophosphate (PRPP). Here, equilibrium binding, isotope partitioning, and chemical quench studies were used to...