C Grubmeyer
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Explore the profile of C Grubmeyer including associated specialties, affiliations and a list of published articles.
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44
Citations
1020
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Recent Articles
11.
Sharma V, Grubmeyer C, Sacchettini J
Structure
. 1998 Dec;
6(12):1587-99.
PMID: 9862811
Background: . Mycobacterium tuberculosis is the single most deadly human pathogen and is responsible for nearly three million deaths every year. Recent elucidation of the mode of action of isoniazid,...
12.
Gross J, Rajavel M, Grubmeyer C
Biochemistry
. 1998 May;
37(12):4189-99.
PMID: 9521741
Nicotinic acid phosphoribosyltransferase (NAPRTase; EC 2.4.2.11) is a facultative ATPase that uses the energy of ATP hydrolysis to drive the synthesis of nicotinate mononucleotide and pyrophosphate from nicotinic acid (NA)...
13.
Rajavel M, Lalo D, Gross J, Grubmeyer C
Biochemistry
. 1998 May;
37(12):4181-8.
PMID: 9521740
Nicotinic acid phosphoribosyltransferase (NAPRTase; EC 2.4.2.11) forms nicotinic acid mononucleotide (NAMN) and PPi from 5-phosphoribosyl 1-pyrophosphate (PRPP) and nicotinic acid (NA). The Vmax NAMN synthesis activity of the Salmonella typhimurium...
14.
Xu Y, Grubmeyer C
Biochemistry
. 1998 May;
37(12):4114-24.
PMID: 9521733
Hypoxanthine-guanine phosphoribosyltransferase (HGPRTase) catalyzes the reversible formation of IMP and GMP from their respective bases hypoxanthine (Hx) and guanine (Gua) and the phosphoribosyl donor 5-phosphoribosyl-1-pyrophosphate (PRPP). The net formation and...
15.
Xu Y, Eads J, Sacchettini J, Grubmeyer C
Biochemistry
. 1997 Mar;
36(12):3700-12.
PMID: 9132023
Hypoxanthine-guanine phosphoribosyltransferase (HGPRTase) is the locus of Lesch-Nyhan syndrome, the activator of the prodrugs 6-mercaptopurine and allopurinol, and a target for antiparasitic chemotherapy. The three-dimensional structure of the recombinant human...
16.
A new function for a common fold: the crystal structure of quinolinic acid phosphoribosyltransferase
Eads J, Ozturk D, Wexler T, Grubmeyer C, Sacchettini J
Structure
. 1997 Jan;
5(1):47-58.
PMID: 9016724
Background: Quinolinic acid (QA) is a neurotoxin and has been shown to be present at high levels in the central nervous system of patients with certain diseases, such as AIDS...
17.
Garriga J, Segura E, Mayol X, Grubmeyer C, Grana X
Biochem J
. 1996 Dec;
320 ( Pt 3):983-9.
PMID: 9003389
PITALRE is a human protein kinase belonging to the cell division cycle 2 (CDC2) kinase family, and is the catalytic subunit of a multimeric complex that contains several cellular proteins....
18.
Gross J, Rajavel M, Segura E, Grubmeyer C
Biochemistry
. 1996 Apr;
35(13):3917-24.
PMID: 8672422
Energy coupling between ATP hydrolysis and other enzyme reactions requires the phosphorylation of substrate-derived intermediates, or the existence of enzyme-derived intermediates capable of storage and transfer of energy. Salmonella typhimurium...
19.
Rajavel M, Gross J, Segura E, MOORE W, Grubmeyer C
Biochemistry
. 1996 Apr;
35(13):3909-16.
PMID: 8672421
Nicotinic acid phosphoribosyltransferase (NAPRTase;EC 2.4.2.11) couples stoichiometric ATP hydrolysis with formation of nicotinate mononucleotide (NAMN) from nicotinic acid and alpha-D-5-phosphoribosyl 1-pyrophosphate (PRPP). Trypsin rapidly inactivated the ATPase and NAMN synthesis...
20.
Tao W, Grubmeyer C, Blanchard J
Biochemistry
. 1996 Jan;
35(1):14-21.
PMID: 8555167
Orotate phosphoribosyltransferase (OPRTase) catalyzes the magnesium-dependent conversion of alpha-D-phosphoribosylpyrophosphate (PRPP) and orotate to orotidine 5'-monophosphate (OMP) and pyrophosphate. We have determined kinetic isotope effects on the reaction of OMP with...