C Frank Bennett
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Explore the profile of C Frank Bennett including associated specialties, affiliations and a list of published articles.
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158
Citations
19364
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Recent Articles
11.
Muinos-Buhl A, Rombo R, Ling K, Zilio E, Rigo F, Bennett C, et al.
Int J Mol Sci
. 2023 Feb;
24(4).
PMID: 36835624
For SMA patients with only two copies, available therapies might be insufficient to counteract lifelong motor neuron (MN) dysfunction. Therefore, additional SMN-independent compounds, supporting SMN-dependent therapies, might be beneficial. Neurocalcin...
12.
Thornton C, Moxley 3rd R, Eichinger K, Heatwole C, Mignon L, Arnold W, et al.
Lancet Neurol
. 2023 Feb;
22(3):218-228.
PMID: 36804094
Background: Myotonic dystrophy type 1 results from an RNA gain-of-function mutation, in which DM1 protein kinase (DMPK) transcripts carrying expanded trinucleotide repeats exert deleterious effects. Antisense oligonucleotides (ASOs) provide a...
13.
Han K, Theodore D, McMullen G, Swayze E, McCaleb M, Billioud G, et al.
Clin Pharmacol Drug Dev
. 2022 Aug;
11(10):1191-1202.
PMID: 35971951
Dose-dependent reductions in hepatitis B virus (HBV) RNA, DNA, and viral proteins following bepirovirsen administration were observed in HepG2.2.15 cells. In HBV-transgenic mice treated at 50 mg/kg/wk, hepatic HBV RNA...
14.
Ait Benichou S, Jauvin D, De Serres-Berard T, Pierre M, Ling K, Bennett C, et al.
Gene Ther
. 2022 Jan;
29(12):698-709.
PMID: 35075265
Myotonic dystrophy, or dystrophia myotonica type 1 (DM1), is a multi-systemic disorder and is the most common adult form of muscular dystrophy. It affects not only muscles but also many...
15.
Ma W, Voss D, Scharner J, Costa A, Lin K, Jeon H, et al.
Cancer Res
. 2021 Dec;
82(5):900-915.
PMID: 34921016
Significance: Antisense oligonucleotides are used to induce a change in PKM isoform usage in hepatocellular carcinoma, reversing the Warburg effect and inhibiting tumorigenesis.
16.
Yuen M, Heo J, Jang J, Yoon J, Kweon Y, Park S, et al.
Nat Med
. 2021 Oct;
27(10):1725-1734.
PMID: 34642494
Chronic infection with hepatitis B virus (HBV) leads to an increased risk of death from cirrhosis and hepatocellular carcinoma. Functional cure rates are low with current treatment options (nucleos(t)ide analogs...
17.
Nagata T, Dwyer C, Yoshida-Tanaka K, Ihara K, Ohyagi M, Kaburagi H, et al.
Nat Biotechnol
. 2021 Aug;
39(12):1529-1536.
PMID: 34385691
Achieving regulation of endogenous gene expression in the central nervous system (CNS) with antisense oligonucleotides (ASOs) administered systemically would facilitate the development of ASO-based therapies for neurological diseases. We demonstrate...
18.
Finkel R, Chiriboga C, Vajsar J, Day J, Montes J, De Vivo D, et al.
Lancet Child Adolesc Health
. 2021 Jun;
5(7):491-500.
PMID: 34089650
Background: Nusinersen showed a favourable benefit-risk profile in participants with infantile-onset spinal muscular atrophy at the interim analysis of a phase 2 clinical study. We present the study's final analysis,...
19.
Maimon R, Chillon-Marinas C, Snethlage C, Singhal S, McAlonis-Downes M, Ling K, et al.
Nat Neurosci
. 2021 Jun;
24(8):1089-1099.
PMID: 34083786
Methods to enhance adult neurogenesis by reprogramming glial cells into neurons enable production of new neurons in the adult nervous system. Development of therapeutically viable approaches to induce new neurons...
20.
Puttaraju M, Jackson M, Klein S, Shilo A, Bennett C, Gordon L, et al.
Nat Med
. 2021 Jun;
27(7):1309.
PMID: 34075250
No abstract available.