Alpha 2.0
Login Register
» Authors » C Dorrell

C Dorrell

Explore the profile of C Dorrell including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 338
Followers 0
Related Specialties
Hematology
Science
Pharmacology
Top 10 Co-Authors
O I Gan
J E Dick
D S Pereira
G Guenechea
C Y Ito
M Kelly
J P Zou
P R Streeter
A J Fox
T Inamitsu
Published In
Proc Natl Acad Sci U S A
Mol Ther
Diabetologia
Exp Hematol
Nat Immunol
Affiliations
Soon will be listed here.
Recent Articles
1.
Transcriptomes of the major human pancreatic cell types
Dorrell C, Schug J, Lin C, Canaday P, Fox A, Smirnova O, et al.
Diabetologia . 2011 Sep; 54(11):2832-44. PMID: 21882062
Aims/hypothesis: We sought to determine the mRNA transcriptome of all major human pancreatic endocrine and exocrine cell subtypes, including human alpha, beta, duct and acinar cells. In addition, we identified...
2.
In vivo dynamics of human stem cell repopulation in NOD/SCID mice
Dick J, Guenechea G, Gan O, Dorrell C
Ann N Y Acad Sci . 2001 Jul; 938:184-90. PMID: 11458507
Primitive human hematopoietic cells can be assayed on the basis of their ability to repopulate immune-deficient NOD/SCID mice and have been termed SCID repopulating cells (SRCs). The in vivo biological...
3.
Distinct classes of human stem cells that differ in proliferative and self-renewal potential
Guenechea G, Gan O, Dorrell C, Dick J
Nat Immunol . 2001 Mar; 2(1):75-82. PMID: 11135582
The composition of the human hematopoietic stem cell compartment is poorly understood due to the absence of experimental tools with which to characterize the developmental program of individual stem cells....
4.
Transduction of human CD34+ CD38- bone marrow and cord blood-derived SCID-repopulating cells with third-generation lentiviral vectors
Guenechea G, Gan O, Inamitsu T, Dorrell C, Pereira D, Kelly M, et al.
Mol Ther . 2000 Aug; 1(6):566-73. PMID: 10933981
The major limitations of Moloney murine leukemia virus (MoMLV)-based vectors for human stem cell applications, particularly those requiring bone marrow (BM) stem cells, include their requirement for mitosis and retroviral...
5.
Expansion of human cord blood CD34(+)CD38(-) cells in ex vivo culture during retroviral transduction without a corresponding increase in SCID repopulating cell (SRC) frequency: dissociation of SRC phenotype and function
Dorrell C, Gan O, Pereira D, Hawley R, Dick J
Blood . 1999 Dec; 95(1):102-10. PMID: 10607692
Current procedures for the genetic manipulation of hematopoietic stem cells are relatively inefficient due, in part, to a poor understanding of the conditions for ex vivo maintenance or expansion of...
6.
Characterization and retroviral transduction of an early human lymphomyeloid precursor assayed in nonswitched long-term culture on murine stroma
Gan O, Dorrell C, Pereira D, Ito C, Wang J, Dick J
Exp Hematol . 1999 Jun; 27(6):1097-106. PMID: 10378899
In the hierarchy of human hematopoietic progenitors, long-term culture-initiating cells (LTC-IC) and extended LTC-IC belong to the earliest cell populations that can be assayed in vitro. We report the identification...
7.
Retroviral transduction of TLS-ERG initiates a leukemogenic program in normal human hematopoietic cells
Pereira D, Dorrell C, Ito C, Gan O, Murdoch B, Rao V, et al.
Proc Natl Acad Sci U S A . 1998 Jul; 95(14):8239-44. PMID: 9653171
Many chimeric oncogenes have been identified by virtue of the association between chromosomal translocation and specific human leukemias. However, the biological mechanism by which these oncogenes disrupt the developmental program...