G Guenechea
Overview
Explore the profile of G Guenechea including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
222
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0
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Recent Articles
1.
Abdul-Razak H, Rocca C, Howe S, Alonso-Ferrero M, Wang J, Gabriel R, et al.
Sci Rep
. 2018 May;
8(1):8214.
PMID: 29844458
Genome editing is the introduction of directed modifications in the genome, a process boosted to therapeutic levels by designer nucleases. Building on the experience of ex vivo gene therapy for...
2.
Navarro S, Moleiro V, Molina-Estevez F, Lozano M, Chinchon R, Almarza E, et al.
Stem Cells
. 2014 Jan;
32(2):436-46.
PMID: 24420904
Fanconi anemia (FA) is a complex genetic disease associated with a defective DNA repair pathway known as the FA pathway. In contrast to many other FA proteins, BRCA2 participates downstream...
3.
Herrero M, Sabater L, Guenechea G, Sendra L, Montilla A, Abargues R, et al.
Gene Ther
. 2011 Oct;
19(5):504-12.
PMID: 21993175
Hydrodynamic injection is an efficient procedure for liver gene therapy in rodents but with limited efficacy in large animals, using an 'in vivo' adapted regional hydrodynamic gene delivery system. We...
4.
Ramirez M, Segovia J, Benet I, Arbona C, Guenechea G, Blaya C, et al.
Br J Haematol
. 2001 Nov;
115(1):213-21.
PMID: 11722435
We have investigated the influence of ex vivo expansion of human CD34(+) cord blood cells on the expression and function of adhesion molecules involved in the homing and engraftment of...
5.
Dick J, Guenechea G, Gan O, Dorrell C
Ann N Y Acad Sci
. 2001 Jul;
938:184-90.
PMID: 11458507
Primitive human hematopoietic cells can be assayed on the basis of their ability to repopulate immune-deficient NOD/SCID mice and have been termed SCID repopulating cells (SRCs). The in vivo biological...
6.
Guenechea G, Gan O, Dorrell C, Dick J
Nat Immunol
. 2001 Mar;
2(1):75-82.
PMID: 11135582
The composition of the human hematopoietic stem cell compartment is poorly understood due to the absence of experimental tools with which to characterize the developmental program of individual stem cells....
7.
Lamana M, Segovia J, Guenechea G, Bueren J
J Gene Med
. 2001 Mar;
3(1):32-41.
PMID: 11269334
Background: The transduction of human peripheral blood T cells with retroviral vectors constitutes an attractive approach for the correction of a number of genetic diseases. In this study we have...
8.
Guenechea G, Gan O, Inamitsu T, Dorrell C, Pereira D, Kelly M, et al.
Mol Ther
. 2000 Aug;
1(6):566-73.
PMID: 10933981
The major limitations of Moloney murine leukemia virus (MoMLV)-based vectors for human stem cell applications, particularly those requiring bone marrow (BM) stem cells, include their requirement for mitosis and retroviral...
9.
Barquinero J, Segovia J, Ramirez M, Limon A, Guenechea G, Puig T, et al.
Blood
. 2000 May;
95(10):3085-93.
PMID: 10807773
In an attempt to develop efficient procedures of human hematopoietic gene therapy, retrovirally transduced CD34(+) cord blood cells were transplanted into NOD/SCID mice to evaluate the repopulating potential of transduced...
10.
Albella B, Segovia J, Guenechea G, Pragnell I, Bueren J
Transplantation
. 1999 Jun;
67(10):1348-57.
PMID: 10360589
Background: The ex vivo expansion of hematopoietic grafts has been proposed as an efficient procedure for improving the hematological recovery of recipients. The fate of the long-term repopulating cells during...