C David Williams
Overview
Explore the profile of C David Williams including associated specialties, affiliations and a list of published articles.
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Articles
32
Citations
1730
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Recent Articles
1.
A mechanism for sarcomere breathing: volume change and advective flow within the myofilament lattice
Cass J, Williams C, Irving T, Lauga E, Malingen S, Daniel T, et al.
Biophys J
. 2021 Aug;
120(18):4079-4090.
PMID: 34384761
During muscle contraction, myosin motors anchored to thick filaments bind to and slide actin thin filaments. These motors rely on energy derived from ATP, supplied, in part, by diffusion from...
2.
Cass J, Williams C, Theriot J
PLoS One
. 2020 May;
15(5):e0221841.
PMID: 32379846
Cells are crowded and spatially heterogeneous, complicating the transport of organelles, proteins and other substrates. One aspect of this complex physical environment, the mobility of passively transported substrates, can be...
3.
Vasan R, Maleckar M, Williams C, Rangamani P
Biophys J
. 2019 Oct;
117(9):1714-1727.
PMID: 31648791
Cell shapes and connectivities evolve over time as the colony changes shape or embryos develop. Shapes of intercellular interfaces are closely coupled with the forces resulting from actomyosin interactions, membrane...
4.
Powers J, Williams C, Regnier M, Daniel T
Integr Comp Biol
. 2018 Jun;
58(2):186-193.
PMID: 29897447
In striated muscle, the giant protein titin spans the entire length of a half-sarcomere and extends from the backbone of the thick filament, reversibly attaches to the thin filaments, and...
5.
Woolbright B, Williams C, Ni H, Kumer S, Schmitt T, Kane B, et al.
Toxicon
. 2016 Nov;
125:99-109.
PMID: 27889601
Microcystins are a group of toxins produced by freshwater cyanobacteria. Uptake of microcystin-leucine arginine (MC-LR) by organic anion transporting polypeptide 1B2 in hepatocytes results in inhibition of protein phosphatase 1A...
6.
Williams C, Biewener A
Proc Natl Acad Sci U S A
. 2015 Mar;
112(11):3392-6.
PMID: 25733863
Individuals traversing challenging obstacles are faced with a decision: they can adopt traversal strategies that minimally disrupt their normal locomotion patterns or they can adopt strategies that substantially alter their...
7.
Du K, Williams C, McGill M, Jaeschke H
Toxicol Appl Pharmacol
. 2014 Sep;
281(1):58-66.
PMID: 25218290
Unlabelled: Acetaminophen (APAP) overdose causes severe hepatotoxicity in animals and humans. However, the mechanisms underlying the gender differences in susceptibility to APAP overdose in mice have not been clarified. In...
8.
McGill M, Cao M, Svetlov A, Sharpe M, Williams C, Curry S, et al.
Biomarkers
. 2014 Mar;
19(3):222-30.
PMID: 24597531
Context: New biomarkers are needed in acetaminophen (APAP) hepatotoxicity. Plasma argininosuccinate synthetase (ASS) is a promising candidate. Objective: Characterize ASS in APAP hepatotoxicity. Methods: ASS was measured in plasma from...
9.
Williams C, Bajt M, Sharpe M, McGill M, Farhood A, Jaeschke H
Toxicol Appl Pharmacol
. 2014 Jan;
275(2):122-33.
PMID: 24440789
Following acetaminophen (APAP) overdose there is an inflammatory response triggered by the release of cellular contents from necrotic hepatocytes into the systemic circulation which initiates the recruitment of neutrophils into...
10.
Williams C, McGill M, Lebofsky M, Bajt M, Jaeschke H
Toxicol Appl Pharmacol
. 2013 Dec;
274(3):417-24.
PMID: 24345528
Acetaminophen (APAP) overdose causes severe and occasionally fatal liver injury. Numerous drugs that attenuate APAP toxicity have been described. However these compounds frequently protect by cytochrome P450 inhibition, thereby preventing...