C D Strader
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Explore the profile of C D Strader including associated specialties, affiliations and a list of published articles.
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127
Citations
2718
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Recent Articles
1.
Strader C
Curr Protoc Neurosci
. 2008 Apr;
Chapter 4:Unit 4.9.
PMID: 18428492
Several mutagenesis strategies have been used to allow the identification of specific receptor-ligand interactions to support the docking of ligands within various receptor models. The strengths and limitations of each...
2.
Lachowicz J, Duffy R, Ruperto V, Kozlowski J, Zhou G, Clader J, et al.
Life Sci
. 2001 Jun;
68(22-23):2585-92.
PMID: 11392630
Current treatment of Alzheimer's Disease (AD) requires acetylcholinesterase inhibition to increase acetylcholine (ACh) concentrations in the synaptic cleft. Another mechanism by which ACh levels can be increased is blockade of...
3.
Ok H, Reigle L, Candelore M, Cascieri M, Colwell L, Deng L, et al.
Bioorg Med Chem Lett
. 2000 Jul;
10(14):1531-4.
PMID: 10915043
As a part of our investigation into the development of orally bioavailable beta3 adrenergic receptor agonists, we have identified a series of substituted oxazole derivatives that are potent beta3 agonists...
4.
Biftu T, Feng D, Liang G, Kuo H, Qian X, Naylor E, et al.
Bioorg Med Chem Lett
. 2000 Jul;
10(13):1431-4.
PMID: 10888325
Benzyl and phenoxymethylene substituted oxadiazoles are potent and orally bioavailable beta3 adrenergic receptor (AR) agonists. The 4-trifluormethoxy substituted 5-benzyl oxadiazole 5f has an EC50 of 8 nM in the beta3...
5.
Feng D, Biftu T, Candelore M, Cascieri M, Colwell Jr L, Deng L, et al.
Bioorg Med Chem Lett
. 2000 Jul;
10(13):1427-9.
PMID: 10888324
5-n-Pentyl oxadiazole substituted benzenesulfonamide 8 is a potent and selective beta3 adrenergic receptor agonist (beta3 EC50 = 23 nM, beta1 IC50 = 3000 nM, beta2 IC50 = 3000 nM). The...
6.
MacDonald D, Murgolo N, Zhang R, Durkin J, Yao X, Strader C, et al.
Mol Pharmacol
. 2000 Jun;
58(1):217-25.
PMID: 10860944
A molecular model of the human melanin-concentrating hormone (MCH) peptide was constructed and docked into a helical, bacteriorhodopsin-based model of the recently identified human MCH receptor. From this hormone-receptor complex,...
7.
Hwa J, Witten M, Williams P, Ghibaudi L, Gao J, Salisbury B, et al.
Am J Physiol
. 1999 Nov;
277(5):R1428-34.
PMID: 10564216
Intracerebroventricular (ICV) administration of neuropeptide Y (NPY) has been shown to decrease energy expenditure, induce hypothermia, and stimulate food intake. Recent evidence has suggested that the Y5 receptor may be...
8.
Mathvink R, Barritta A, Candelore M, Cascieri M, Deng L, Tota L, et al.
Bioorg Med Chem Lett
. 1999 Jul;
9(13):1869-74.
PMID: 10406657
A series of compounds possessing an N-substituted indoline-5-sulfonamide pharmacophore was prepared and evaluated for their human beta3 adrenergic receptor agonist activity. The SAR of a wide range of urea and...
9.
Shih T, Candelore M, Cascieri M, Chiu S, Colwell Jr L, Deng L, et al.
Bioorg Med Chem Lett
. 1999 May;
9(9):1251-4.
PMID: 10340609
L-770,644 (9c) is a potent and selective agonist of the human beta3 adrenergic receptor (EC50 = 13 nM). It shows good oral bioavailability in both dogs and rats (%F =...
10.
Naylor E, Parmee E, Colandrea V, Perkins L, Brockunier L, Candelore M, et al.
Bioorg Med Chem Lett
. 1999 Apr;
9(5):755-8.
PMID: 10201842
The cyclopentylpropylimidazolidinone L-766,892 is a potent beta3 AR agonist (EC50 5.7 nM, 64% activation) with 420- and 130-fold selectivity over binding to the beta1 and beta2 ARs, respectively. In anesthetized...