C C Gregorio
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Explore the profile of C C Gregorio including associated specialties, affiliations and a list of published articles.
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28
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1512
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Recent Articles
1.
Gregorio C, Fowler V
Trends Cardiovasc Med
. 2011 Jan;
6(4):136-41.
PMID: 21232287
The regulation of thin filament length is a fundamental property of all striated muscles. Tropomodulin is an actin and tropomyosin binding protein that is exclusively associated with the free (pointed)...
2.
Bang M, Centner T, Fornoff F, Geach A, Gotthardt M, McNabb M, et al.
Circ Res
. 2001 Nov;
89(11):1065-72.
PMID: 11717165
Titin is a giant vertebrate striated muscle protein with critical importance for myofibril elasticity and structural integrity. We show here that the complete sequence of the human titin gene contains...
3.
Furukawa T, Ono Y, Tsuchiya H, Katayama Y, Bang M, Labeit D, et al.
J Mol Biol
. 2001 Nov;
313(4):775-84.
PMID: 11697903
Ion-channel beta-subunits are ancillary proteins that co-assemble with alpha-subunits to modulate gating kinetics and enhance stability of multimeric channel complexes. They provide binding sites for other regulatory proteins and are...
4.
Rudy D, Yatskievych T, Antin P, Gregorio C
Dev Dyn
. 2001 May;
221(1):61-71.
PMID: 11357194
De novo cardiac myofibril assembly has been difficult to study due to the lack of available cell culture models that clearly and accurately reflect heart muscle development in vivo. However,...
5.
Bang M, Mudry R, McElhinny A, Trombitas K, Geach A, Yamasaki R, et al.
J Cell Biol
. 2001 Apr;
153(2):413-27.
PMID: 11309420
We describe here a novel sarcomeric 145-kD protein, myopalladin, which tethers together the COOH-terminal Src homology 3 domains of nebulin and nebulette with the EF hand motifs of alpha-actinin in...
6.
Centner T, Yano J, Kimura E, McElhinny A, Pelin K, Witt C, et al.
J Mol Biol
. 2001 Mar;
306(4):717-26.
PMID: 11243782
The giant myofibrillar protein titin contains within its C-terminal region a serine-threonine kinase of unknown function. We have identified a novel muscle specific RING finger protein, referred to as MURF-1,...
7.
McElhinny A, Kolmerer B, Fowler V, Labeit S, Gregorio C
J Biol Chem
. 2000 Oct;
276(1):583-92.
PMID: 11016930
Strict regulation of actin thin filament length is critical for the proper functioning of sarcomeres, the basic contractile units of myofibrils. It has been hypothesized that a molecular template works...
8.
McElhinny A, Labeit S, Gregorio C
Adv Exp Med Biol
. 2000 Sep;
481:67-86; discussion 86-8.
PMID: 10987067
Sarcomeres of cardiac muscle are comprised of numerous proteins organized in an elegantly precise order. The exact mechanism of how these proteins are assembled into myofibrils during heart development is...
9.
Centner T, Fougerousse F, Freiburg A, Witt C, Beckmann J, Granzier H, et al.
Adv Exp Med Biol
. 2000 Sep;
481:35-49; discussion 50-2.
PMID: 10987065
Although vertebrate genomes appear to contain only one titin gene, a large variety of quite distinct titin isoforms are expressed in striated muscle tissues. The isoforms appear to be generated...
10.
Gregorio C, Antin P
Trends Cell Biol
. 2000 Aug;
10(9):355-62.
PMID: 10932092
One of the most fascinating examples of cytoskeletal assembly is the myofibril, the contractile structure of striated (i.e. skeletal and cardiac) muscle. Myofibrils are composed of repeating contractile units known...