C Basbaum
Overview
Explore the profile of C Basbaum including associated specialties, affiliations and a list of published articles.
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Articles
37
Citations
768
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Recent Articles
1.
Sidhu S, Nawroth R, Retz M, Lemjabbar-Alaoui H, Dasari V, Basbaum C
Oncogene
. 2010 Jun;
29(29):4145-56.
PMID: 20514014
Advances in the field of tumor biology have identified that tumor cells co-opt developmental signaling pathways of embryonic stem cells and thus gain the ability to proliferate, differentiate and alter...
2.
Maltseva I, Fleiszig S, Evans D, Kerr S, Sidhu S, McNamara N, et al.
Exp Eye Res
. 2007 May;
85(1):142-53.
PMID: 17531223
Bacterial keratitis is a sight-threatening complication of contact lens wear, and Pseudomonas aeruginosa is a commonly isolated pathogen. The mechanisms by which lenses predispose the cornea to P. aeruginosa infection...
3.
Retz M, Sidhu S, Lehmann J, Tamamura H, Fujii N, Basbaum C
Eur Urol
. 2005 Sep;
48(6):1025-30.
PMID: 16140456
Objective: The CXCR4/CXCL12 axis appears crucial in the metastasis of bladder cancer. Our aim was to evaluate the potency of the CXCR4 antagonist, 4F-benzoyl-TE14011 (4F-bTE), as an anti-metastatic drug in...
4.
McNamara N, Basbaum C
Glycoconj J
. 2002 Oct;
18(9):715-22.
PMID: 12386457
Human lung cells exposed to pathogenic bacteria upregulate the production of mucin, the major macromolecular component of mucus. Generally this upregulation is beneficial for the host, however, in the lungs...
5.
McNamara N, Khong A, McKemy D, Caterina M, Boyer J, Julius D, et al.
Proc Natl Acad Sci U S A
. 2001 Aug;
98(16):9086-91.
PMID: 11481474
The flagella of the Gram-negative bacterium Pseudomonas aeruginosa serve not only for motility but also to bind bacteria to the host cell glycolipid asialoGM1 (ASGM1) through the protein flagellin. This...
6.
Gray T, Nettesheim P, Basbaum C, Koo J
Biochem J
. 2001 Feb;
353(Pt 3):727-34.
PMID: 11171071
We reported previously that the expression of the gene encoding MUC5AC mucin in human airway epithelial cells is controlled by retinoic acid via the retinoic acid receptor (RAR)-alpha and that...
7.
Belcher C, Drenkow J, Kehoe B, Gingeras T, McNamara N, Lemjabbar H, et al.
Proc Natl Acad Sci U S A
. 2000 Nov;
97(25):13847-52.
PMID: 11087813
Bordetella pertussis, the causative agent of whooping cough, has many well-studied virulence factors and a characteristic clinical presentation. Despite this information, it is not clear how B. pertussis interaction with...
8.
Hisatsune A, Uto A, Koyanagi T, Chihara T, Miyata T, Basbaum C, et al.
Nihon Yakurigaku Zasshi
. 2000 Jan;
114 Suppl 1:81P-85P.
PMID: 10629860
Lysozyme is an important component of innate immunity against common pathogens at mucosal surfaces. We previously cloned and characterized the bovine lysozyme 5A (lys5A) promoter with the purpose of determining...
9.
Longphre M, Li D, Gallup M, Drori E, Ordonez C, REDMAN T, et al.
J Clin Invest
. 1999 Nov;
104(10):1375-82.
PMID: 10562299
A hallmark of asthma is mucin overproduction, a condition that contributes to airway obstruction. The events responsible for mucin overproduction are not known but are thought to be associated with...
10.
Basbaum C, Lemjabbar H, Longphre M, Li D, Gensch E, McNamara N
Am J Respir Crit Care Med
. 1999 Nov;
160(5 Pt 2):S44-8.
PMID: 10556169
Mucin production is an evolutionarily ancient defense mechanism that is retained in mammals and operates at all mucosal surfaces to protect the host against pathogens and irritants. As in lower...