C A Spilburg
Overview
Explore the profile of C A Spilburg including associated specialties, affiliations and a list of published articles.
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Articles
25
Citations
162
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Recent Articles
1.
Ostlund Jr R, Spilburg C, Stenson W
Am J Clin Nutr
. 1999 Oct;
70(5):826-31.
PMID: 10539742
Background: Phytosterol feeding in human clinical trials has had generally small and inconsistent effects on serum cholesterol concentrations, raising doubts about the importance of phytosterols in natural diets and supplements....
2.
Chen J, Miercke L, Krucinski J, Starr J, Saenz G, Wang X, et al.
Biochemistry
. 1998 May;
37(15):5107-17.
PMID: 9548741
The structure of pancreatic cholesterol esterase, an enzyme that hydrolyzes a wide variety of dietary lipids, mediates the absorption of cholesterol esters, and is dependent on bile salts for optimal...
3.
Spilburg C, Cox D, Wang X, Bernat B, Bosner M, Lange L
Biochemistry
. 1995 Nov;
34(47):15532-8.
PMID: 7492555
All mammalian pancreatic cholesterol esterases (CEase) bind to membrane-associated heparin at a single site on the intestinal brush border membrane with a dissociation constant of 100 nM. While the enzyme...
4.
Lopez-Candales A, Bosner M, Spilburg C, Lange L
Biochemistry
. 1993 Nov;
32(45):12085-9.
PMID: 8218286
We have recently hypothesized that neutral lipids can, in part, move across biological membranes via a mechanism involving enzymes anchored to membrane proteoglycans such as those found in the brush...
5.
Kumar B, Colwell N, Lopez-Candales A, Bosner M, Spilburg C, Lowe M, et al.
Biochemistry
. 1992 Jul;
31(26):6077-81.
PMID: 1627550
The gene for human pancreatic cholesterol esterase consists of 11 exons and 10 introns and is 9.2 kb in length. The last and longest exon (841 nucleotides) is unique to...
6.
Bora P, Wu X, Spilburg C, Lange L
J Biol Chem
. 1992 Jul;
267(19):13217-21.
PMID: 1618826
Fatty acid ethyl ester synthases metabolize ethanol nonoxidatively in those extrahepatic organs most commonly damaged by alcohol abuse. This study was designed to isolate and purify human myocardial synthase-II, one...
7.
Kyger E, Riley D, Spilburg C, Lange L
Biochemistry
. 1990 Apr;
29(16):3853-8.
PMID: 2354156
The ability of cholesterol esterase to catalyze the synthesis of cholesterol esters has been considered to be of limited physiological significance because of its bile salt requirements for activity, though...
8.
Riley D, Kyger E, Spilburg C, Lange L
Biochemistry
. 1990 Apr;
29(16):3848-52.
PMID: 2354155
Human pancreatic fatty acid ethyl ester synthase has been isolated and purified 1200-fold to homogeneity, and its activities, binding properties, and N-terminal amino acid sequence indicate that it is a...
9.
Cox D, Leung C, Kyger E, Spilburg C, Lange L
Biochemistry
. 1990 Apr;
29(16):3842-8.
PMID: 2354154
The activities of pancreatic cholesterol esterase from calf and cow pancreas were examined in detail. A 1300-fold enhancement of enzymatic activity was found after maturation, even though cholesterol esterase activity...
10.
Bosner M, Gulick T, Riley D, Spilburg C, Lange L
J Biol Chem
. 1989 Dec;
264(34):20261-4.
PMID: 2584217
Utilizing small intestine membranes that contain heparin (50 micrograms/mg protein), binding of triglyceride lipase (homogeneous 52 kDa, specific activity, 70 nmol/mg.h) to membranes was shown to be concentration dependent and...