C A Janson
Overview
Explore the profile of C A Janson including associated specialties, affiliations and a list of published articles.
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48
Citations
1080
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Recent Articles
11.
Khandekar S, Konstantinidis A, SILVERMAN C, Janson C, McNulty D, Nwagwu S, et al.
Biochem Biophys Res Commun
. 2000 Mar;
270(1):100-7.
PMID: 10733911
Bacterial beta-ketoacyl-acyl carrier protein (ACP) synthase III (KAS III, also called FabH) catalyzes the condensation and transacylation of acetyl-CoA with malonyl-ACP. In order to understand the mode of enzyme/substrate interaction...
12.
Qiu X, Janson C, Court R, Smyth M, Payne D, Abdel-Meguid S
Protein Sci
. 1999 Dec;
8(11):2529-32.
PMID: 10595560
The crystal structure of the Escherichia coli enoyl reductase-NAD+-triclosan complex has been determined at 2.5 A resolution. The Ile192-Ser198 loop is either disordered or in an open conformation in the...
13.
Qiu X, Janson C, Konstantinidis A, Nwagwu S, SILVERMAN C, Smith W, et al.
J Biol Chem
. 1999 Dec;
274(51):36465-71.
PMID: 10593943
Beta-ketoacyl-acyl carrier protein synthase III (FabH), the most divergent member of the family of condensing enzymes, is a key catalyst in bacterial fatty acid biosynthesis and a promising target for...
14.
Qiu X, Janson C, Blackburn M, Chhohan I, Hibbs M, Abdel-Meguid S
Biochemistry
. 1999 Sep;
38(38):12296-304.
PMID: 10493797
The crystal structure of the Staphylococcus aureus histidyl-tRNA synthetase apoprotein has been determined at 2.7 A resolution. Several important loops in the active site either become disordered or adopt very...
15.
Marquis R, Ru Y, Yamashita D, Oh H, Yen J, Thompson S, et al.
Bioorg Med Chem
. 1999 Jun;
7(4):581-8.
PMID: 10353637
Cathepsin K (EC 3.4.22.38) is a cysteine protease of the papain superfamily which is selectively expressed within the osteoclast. Several lines of evidence have pointed to the fact that this...
16.
LaLonde J, Zhao B, Janson C, Dalessio K, McQueney M, Orsini M, et al.
Biochemistry
. 1999 Jan;
38(3):862-9.
PMID: 9893980
Cathepsin K is a cysteine protease present in human osteoclasts that plays an important role in bone resorption. Cathepsin K is synthesized as an inactive proenzyme and activated under conditions...
17.
LaLonde J, Zhao B, Smith W, Janson C, DesJarlais R, Tomaszek T, et al.
J Med Chem
. 1998 Nov;
41(23):4567-76.
PMID: 9804696
Papain has been used as a surrogate enzyme in a drug design effort to obtain potent and selective inhibitors of cathepsin K, a new member of the papain superfamily of...
18.
Thompson S, Smith W, Zhao B, Halbert S, Tomaszek T, Tew D, et al.
J Med Chem
. 1998 Oct;
41(21):3923-7.
PMID: 9767629
Peptidomimetic cathepsin K inhibitors have been designed using binding models which were based on the X-ray crystal structure of an amino acid-based, active site-spanning inhibitor complexed with cathepsin K. These...
19.
Marquis R, Yamashita D, Ru Y, LoCastro S, Oh H, Erhard K, et al.
J Med Chem
. 1998 Sep;
41(19):3563-7.
PMID: 9733481
No abstract available.
20.
Thompson S, Halbert S, Bossard M, Tomaszek T, Levy M, Zhao B, et al.
Proc Natl Acad Sci U S A
. 1998 Feb;
94(26):14249-54.
PMID: 9405598
Potent and selective active-site-spanning inhibitors have been designed for cathepsin K, a cysteine protease unique to osteoclasts. They act by mechanisms that involve tight binding intermediates, potentially on a hydrolytic...