Bryan Zimdahl
Overview
Explore the profile of Bryan Zimdahl including associated specialties, affiliations and a list of published articles.
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12
Citations
694
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0
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Recent Articles
1.
He P, Liu H, Zimdahl B, Wang J, Luo M, Chang Q, et al.
J Cancer Res Clin Oncol
. 2022 Jul;
149(7):2757-2769.
PMID: 35776199
Purpose: A barrier to widespread adoption of chimeric antigen receptor (CAR) T-cell therapy is toxicity. To address this, we recently developed a novel antibody-T-cell receptor (AbTCR) platform (trademarked as ARTEMIS)...
2.
Spinler K, Bajaj J, Ito T, Zimdahl B, Hamilton M, Ahmadi A, et al.
Nat Commun
. 2020 Nov;
11(1):5998.
PMID: 33243988
Intratumoral heterogeneity is a common feature of many myeloid leukemias and a significant reason for treatment failure and relapse. Thus, identifying the cells responsible for residual disease and leukemia re-growth...
3.
Xu Y, Yang Z, Horan L, Zhang P, Liu L, Zimdahl B, et al.
Cell Discov
. 2018 Nov;
4:62.
PMID: 30479831
The clinical use of genetically modified T-cell therapies has led to unprecedented response rates in leukemia and lymphoma patients treated with anti-CD19 chimeric antigen receptor (CAR)-T. Despite this clinical success,...
4.
Tevlin R, Seo E, Marecic O, McArdle A, Tong X, Zimdahl B, et al.
Sci Transl Med
. 2017 Jan;
9(372).
PMID: 28077677
Diabetes mellitus (DM) is a metabolic disease frequently associated with impaired bone healing. Despite its increasing prevalence worldwide, the molecular etiology of DM-linked skeletal complications remains poorly defined. Using advanced...
5.
Lee J, Rothenberg M, Seeley E, Zimdahl B, Kawano S, Lu W, et al.
Proc Natl Acad Sci U S A
. 2016 Nov;
113(47):E7545-E7553.
PMID: 27815529
Inflammation disrupts tissue architecture and function, thereby contributing to the pathogenesis of diverse diseases; the signals that promote or restrict tissue inflammation thus represent potential targets for therapeutic intervention. Here,...
6.
Liu H, Xu Y, Xiang J, Long L, Green S, Yang Z, et al.
Clin Cancer Res
. 2016 Aug;
23(2):478-488.
PMID: 27535982
Purpose: The majority of tumor-specific antigens are intracellular and/or secreted and therefore inaccessible by conventional chimeric antigen receptor (CAR) T-cell therapy. Given that all intracellular/secreted proteins are processed into peptides...
7.
Koechlein C, Harris J, Lee T, Weeks J, Fox R, Zimdahl B, et al.
Nat Commun
. 2016 Jul;
7:12169.
PMID: 27425143
Although we know a great deal about the phenotype and function of haematopoietic stem/progenitor cells, a major challenge has been mapping their dynamic behaviour within living systems. Here we describe...
8.
Fox R, Lytle N, Jaquish D, Park F, Ito T, Bajaj J, et al.
Nature
. 2016 Jun;
534(7607):407-411.
PMID: 27281208
Pancreatic intraepithelial neoplasia is a pre-malignant lesion that can progress to pancreatic ductal adenocarcinoma, a highly lethal malignancy marked by its late stage at clinical presentation and profound drug resistance....
9.
Bajaj J, Zimdahl B, Reya T
Cancer Res
. 2015 Feb;
75(5):792-7.
PMID: 25681272
Asymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants. While asymmetric division is critically important in generating diversity...
10.
Zimdahl B, Ito T, Blevins A, Bajaj J, Konuma T, Weeks J, et al.
Nat Genet
. 2014 Feb;
46(3):245-52.
PMID: 24487275
Cell fate can be controlled through asymmetric division and segregation of protein determinants, but the regulation of this process in the hematopoietic system is poorly understood. Here we show that...