Bryan L Wharram
Overview
Explore the profile of Bryan L Wharram including associated specialties, affiliations and a list of published articles.
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10
Citations
982
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Recent Articles
1.
Buschhaus J, Rajendran S, Chen S, Wharram B, Bevoor A, Cutter A, et al.
Mol Cancer Res
. 2023 Feb;
21(5):458-471.
PMID: 36735350
Implications: This study reveals how MSCs reprogram metabolism of ER+ breast cancer cells and point to MCT4 as potential therapeutic target to overcome resistance to antiestrogen drugs.
2.
Wiggins J, Patel S, Shedden K, Goyal M, Wharram B, Martini S, et al.
J Am Soc Nephrol
. 2010 Feb;
21(4):587-97.
PMID: 20150534
The peak prevalence of ESRD from glomerulosclerosis occurs at 70 to 79 years. To understand why old glomeruli are prone to failure, we analyzed the Fischer 344 rat model of...
3.
Charba D, Wiggins R, Goyal M, Wharram B, Wiggins J, McCarthy E, et al.
Am J Physiol Renal Physiol
. 2009 May;
297(1):F138-44.
PMID: 19403647
Glomerular capillary filtration barrier characteristics are determined in part by the slit-pore junctions of glomerular podocytes. Protein tyrosine phosphatase receptor-O (PTPro) is a transmembrane protein expressed on the apical surface...
4.
Sato Y, Wharram B, Lee S, Wickman L, Goyal M, Venkatareddy M, et al.
J Am Soc Nephrol
. 2009 Apr;
20(5):1041-52.
PMID: 19389856
Because loss of podocytes associates with glomerulosclerosis, monitoring podocyte loss by measuring podocyte products in urine may be clinically useful. To determine whether a single episode of podocyte injury would...
5.
Williams A, Wiggins R, Wharram B, Goyal M, Dou C, Johnson K, et al.
Ultrasound Med Biol
. 2007 May;
33(8):1336-44.
PMID: 17507144
The right kidney of anesthetized rats was imaged with intermittent diagnostic ultrasound (1.5 MHz; 1-s trigger interval) under exposure conditions simulating those encountered in human perfusion imaging. The rats were...
6.
Miller D, Dou C, Wiggins R, Wharram B, Goyal M, Williams A
Ultrasound Med Biol
. 2006 Dec;
33(1):129-35.
PMID: 17189055
One kidney of anesthetized rats was imaged by diagnostic ultrasound with contrast agent under conditions simulating both the geometry and the attenuation encountered during human perfusion imaging. Contrary to earlier...
7.
Hinkes B, Wiggins R, Gbadegesin R, Vlangos C, Seelow D, Nurnberg G, et al.
Nat Genet
. 2006 Nov;
38(12):1397-405.
PMID: 17086182
Nephrotic syndrome, a malfunction of the kidney glomerular filter, leads to proteinuria, edema and, in steroid-resistant nephrotic syndrome, end-stage kidney disease. Using positional cloning, we identified mutations in the phospholipase...
8.
Wiggins J, Goyal M, Wharram B, Wiggins R
J Am Soc Nephrol
. 2006 Apr;
17(5):1382-7.
PMID: 16597684
Biologic aging is accelerated by high-calorie intake, increased free radical production, and oxidation of key biomolecules. Fischer 344 rats that are maintained on an ad libitum diet develop oxidant injury...
9.
Wiggins J, Goyal M, Sanden S, Wharram B, Shedden K, Misek D, et al.
J Am Soc Nephrol
. 2005 Aug;
16(10):2953-66.
PMID: 16120818
Whether podocyte depletion could cause the glomerulosclerosis of aging in Fischer 344 rats at ages 2, 6, 17, and 24 mo was evaluated. Ad libitum-fed rats developed proteinuria and glomerulosclerosis...
10.
Wharram B, Goyal M, Wiggins J, Sanden S, Hussain S, Filipiak W, et al.
J Am Soc Nephrol
. 2005 Aug;
16(10):2941-52.
PMID: 16107576
Glomerular injury and proteinuria in diabetes (types 1 and 2) and IgA nephropathy is related to the degree of podocyte depletion in humans. For determining the causal relationship between podocyte...