Roger C Wiggins
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Explore the profile of Roger C Wiggins including associated specialties, affiliations and a list of published articles.
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59
Citations
3348
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Recent Articles
1.
Fukuda A, Sato Y, Shibata H, Fujimoto S, Wiggins R
Clin Exp Nephrol
. 2024 Feb;
28(6):496-504.
PMID: 38402504
A critical degree of podocyte depletion causes glomerulosclerosis, and persistent podocyte loss in glomerular diseases drives the progression to end-stage kidney disease. The extent of podocyte injury at a point...
2.
Bitzer M, Ju W, Subramanian L, Troost J, Tychewicz J, Steck B, et al.
Am J Physiol Renal Physiol
. 2022 Aug;
323(4):F401-F410.
PMID: 35924446
Research on kidney diseases is being transformed by the rapid expansion and innovations in omics technologies. The analysis, integration, and interpretation of big data, however, have been an impediment to...
3.
Menon R, Otto E, Berthier C, Nair V, Farkash E, Hodgin J, et al.
Kidney Int
. 2021 Dec;
101(4):779-792.
PMID: 34952098
Increased podocyte detachment begins immediately after kidney transplantation and is associated with long-term allograft failure. We hypothesized that cell-specific transcriptional changes in podocytes and glomerular endothelial cells after transplantation would...
4.
Naik A, Wang S, Chowdhury M, Aqeel J, OConnor C, Wiggins J, et al.
Sci Rep
. 2021 Oct;
11(1):19605.
PMID: 34599260
Increasing evidence suggests that single in kidney states (e.g., kidney transplantation and living donation) progressive glomerulosclerosis limits kidney lifespan. Modeling shows that post-nephrectomy compensatory glomerular volume (GV) increase drives podocyte...
5.
Naik A, Aqeel J, Wang S, Chowdhury M, He K, Wiggins R
Clin Transplant
. 2021 Aug;
35(11):e14457.
PMID: 34387906
Long-term kidney transplant (KT) survival has remained relatively stagnant. Protocol biopsy studies suggest that glomerulosclerosis is a significant contributor to long-term graft failure. We previously demonstrated that podocyte loss in...
6.
Schaub J, OConnor C, Shi J, Wiggins R, Shedden K, Hodgin J, et al.
J Clin Pathol
. 2021 Jan;
75(2):121-127.
PMID: 33431484
Aims: Detection of one segmentally sclerosed glomerulus (SSG) identifies patients with focal segmental glomerulosclerosis (FSGS) but rare SSGs may be missed in kidney biopsies. It is unknown whether alterations of...
7.
Fukuda A, Minakawa A, Kikuchi M, Sato Y, Nagatomo M, Nakamura S, et al.
Sci Rep
. 2020 Oct;
10(1):18209.
PMID: 33097787
Earlier detection of progression risk in diabetic nephropathy will allow earlier intervention to reduce progression. The hypothesis that urinary pellet podocyte mRNA is a more sensitive progression risk marker than...
8.
Naik A, Le D, Aqeel J, Wang S, Chowdhury M, Walters L, et al.
Kidney Int
. 2020 Aug;
98(3):699-707.
PMID: 32739208
Hypertension-associated progressive glomerulosclerosis is a significant driver of both de novo and all-cause chronic kidney disease leading to end-stage kidney failure. The progression of glomerular disease proceeds via continuing depletion...
9.
Atchison D, OConnor C, Menon R, Otto E, Ganesh S, Wiggins R, et al.
Am J Physiol Renal Physiol
. 2020 Apr;
318(5):F1177-F1187.
PMID: 32223311
Loss-of-function mutations in phospholipase C-ε1 (PLCE1) have been detected in patients with nephrotic syndrome, but other family members with the same mutation were asymptomatic, suggesting additional stressor are required to...
10.
Minakawa A, Fukuda A, Sato Y, Kikuchi M, Kitamura K, Wiggins R, et al.
Sci Rep
. 2019 Dec;
9(1):18485.
PMID: 31811176
Type2 diabetes-associated nephropathy is the commonest cause of renal failure. Mechanisms responsible are controversial. Leptin-deficient hyperphagic Zucker (fa/fa) rats were modeled to test the hypothesis that glomerular enlargement drives podocyte...