Bryan Bryson
Overview
Explore the profile of Bryan Bryson including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
869
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0
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Recent Articles
1.
Singh R, Im C, Qiu Y, Mackness B, Gupta A, Joren T, et al.
Proc Natl Acad Sci U S A
. 2025 Jan;
122(1):e2418918121.
PMID: 39793083
Protein language models (PLMs) have demonstrated impressive success in modeling proteins. However, general-purpose "foundational" PLMs have limited performance in modeling antibodies due to the latter's hypervariable regions, which do not...
2.
Liu N, Kattan W, Mead B, Kummerlowe C, Cheng T, Ingabire S, et al.
Nat Biotechnol
. 2024 Oct;
PMID: 39375446
High-throughput phenotypic screens using biochemical perturbations and high-content readouts are constrained by limitations of scale. To address this, we establish a method of pooling exogenous perturbations followed by computational deconvolution...
3.
Hie B, Kim S, Rando T, Bryson B, Berger B
Nat Protoc
. 2024 Jun;
19(8):2283-2297.
PMID: 38844552
Merging diverse single-cell RNA sequencing (scRNA-seq) data from numerous experiments, laboratories and technologies can uncover important biological insights. Nonetheless, integrating scRNA-seq data encounters special challenges when the datasets are composed...
4.
Singh R, Sledzieski S, Bryson B, Cowen L, Berger B
Proc Natl Acad Sci U S A
. 2023 Jun;
120(24):e2220778120.
PMID: 37289807
Sequence-based prediction of drug-target interactions has the potential to accelerate drug discovery by complementing experimental screens. Such computational prediction needs to be generalizable and scalable while remaining sensitive to subtle...
5.
Nziza N, Jung W, Mendu M, Chen T, McNamara R, Fortune S, et al.
Front Microbiol
. 2023 May;
14:1171990.
PMID: 37228375
Introduction: Placental transfer of maternal antibodies is essential for neonatal immunity over the first months of life. In the setting of maternal HIV infection, HIV-exposed uninfected (HEU) infants are at...
6.
Mead B, Kummerlowe C, Liu N, Kattan W, Cheng T, Cheah J, et al.
bioRxiv
. 2023 Feb;
PMID: 36747859
High-throughput phenotypic screens leveraging biochemical perturbations, high-content readouts, and complex multicellular models could advance therapeutic discovery yet remain constrained by limitations of scale. To address this, we establish a method...
7.
Stopfer L, Rettko N, Leddy O, Mesfin J, Brown E, Winski S, et al.
Proc Natl Acad Sci U S A
. 2022 Dec;
119(49):e2208900119.
PMID: 36454758
Combining multiple therapeutic strategies in NRAS/BRAF mutant melanoma-namely MEK/BRAF kinase inhibitors, immune checkpoint inhibitors (ICIs), and targeted immunotherapies-may offer an improved survival benefit by overcoming limitations associated with any individual...
8.
Nilsson A, Peters J, Meimetis N, Bryson B, Lauffenburger D
Nat Commun
. 2022 Jun;
13(1):3069.
PMID: 35654811
Mammalian cells adapt their functional state in response to external signals in form of ligands that bind receptors on the cell-surface. Mechanistically, this involves signal-processing through a complex network of...
9.
Rosenberg J, Peters J, Hughes T, Lareau C, Ludwig L, Massoth L, et al.
Med
. 2022 May;
3(1):42-57.e5.
PMID: 35590143
Background: Idiopathic aplastic anemia is a potentially lethal disease, characterized by T cell-mediated autoimmune attack of bone marrow hematopoietic stem cells. Standard of care therapies (stem cell transplantation or immunosuppression)...
10.
Gideon H, Hughes T, Tzouanas C, Wadsworth 2nd M, Tu A, Gierahn T, et al.
Immunity
. 2022 Apr;
55(5):827-846.e10.
PMID: 35483355
Mycobacterium tuberculosis lung infection results in a complex multicellular structure: the granuloma. In some granulomas, immune activity promotes bacterial clearance, but in others, bacteria persist and grow. We identified correlates...