Bruno D Fonseca
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Explore the profile of Bruno D Fonseca including associated specialties, affiliations and a list of published articles.
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25
Citations
1915
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Recent Articles
1.
Farooq Z, Kusuma F, Burke P, Dufour C, Lee D, Tabatabaei N, et al.
J Biol Chem
. 2022 Jul;
298(9):102277.
PMID: 35863436
La-related protein 1 (LARP1) has been identified as a key translational inhibitor of terminal oligopyrimidine (TOP) mRNAs downstream of the nutrient sensing protein kinase complex, mTORC1. LARP1 exerts this inhibitory...
2.
Mattijssen S, Kozlov G, Fonseca B, Gehring K, Maraia R
RNA Biol
. 2021 Feb;
18(2):259-274.
PMID: 33522422
La-related proteins (LARPs) share a La motif (LaM) followed by an RNA recognition motif (RRM). Together these are termed the La-module that, in the prototypical nuclear La protein and LARP7,...
3.
Jia J, Lahr R, Solgaard M, Moraes B, Pointet R, Yang A, et al.
Nucleic Acids Res
. 2021 Jan;
49(6):3461-3489.
PMID: 33398329
LARP1 is a key repressor of TOP mRNA translation. It binds the m7Gppp cap moiety and the adjacent 5'TOP motif of TOP mRNAs, thus impeding the assembly of the eIF4F...
4.
Smith E, Benbahouche N, Morris K, Wilczynska A, Gillen S, Schmidt T, et al.
Nucleic Acids Res
. 2020 Dec;
49(1):458-478.
PMID: 33332560
The mammalian target of rapamycin (mTOR) is a critical regulator of cell growth, integrating multiple signalling cues and pathways. Key among the downstream activities of mTOR is the control of...
5.
Mattijssen S, Kozlov G, Gaidamakov S, Ranjan A, Fonseca B, Gehring K, et al.
RNA Biol
. 2020 Dec;
18(2):275-289.
PMID: 33292040
The protein domain arrangement known as the La-module, comprised of a La motif (LaM) followed by a linker and RNA recognition motif (RRM), is found in seven La-related proteins: LARP1,...
6.
Cassidy K, Lahr R, Kaminsky J, Mack S, Fonseca B, Das S, et al.
Structure
. 2019 Nov;
27(12):1771-1781.e5.
PMID: 31676287
The RNA-binding protein La-related protein 1 (LARP1) plays a central role in ribosome biosynthesis. Its C-terminal DM15 region binds the 7-methylguanosine (mG) cap and 5' terminal oligopyrimidine (TOP) motif characteristic...
7.
Leroux L, Lorent J, Graber T, Chaparro V, Masvidal L, Aguirre M, et al.
Infect Immun
. 2018 Jul;
86(9).
PMID: 29967092
The intracellular parasite promotes infection by targeting multiple host cell processes; however, whether it modulates mRNA translation is currently unknown. Here, we show that infection of primary murine macrophages with...
8.
Fonseca B, Lahr R, Damgaard C, Alain T, Berman A
Wiley Interdiscip Rev RNA
. 2018 May;
9(5):e1480.
PMID: 29722158
The ribosome is an essential unit of all living organisms that commands protein synthesis, ultimately fuelling cell growth (accumulation of cell mass) and cell proliferation (increase in cell number). The...
9.
Lahr R, Fonseca B, Ciotti G, Al-Ashtal H, Jia J, Niklaus M, et al.
Elife
. 2017 Apr;
6.
PMID: 28379136
The 5'terminal oligopyrimidine (5'TOP) motif is a -regulatory RNA element located immediately downstream of the 7-methylguanosine [mG] cap of TOP mRNAs, which encode ribosomal proteins and translation factors. In eukaryotes,...
10.
Tsukumo Y, Alain T, Fonseca B, Nadon R, Sonenberg N
Nat Commun
. 2016 Jun;
7:11776.
PMID: 27319316
Targeting mTORC1 is a highly promising strategy in cancer therapy. Suppression of mTORC1 activity leads to rapid dephosphorylation of eIF4E-binding proteins (4E-BP1-3) and subsequent inhibition of mRNA translation. However, how...