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Bruno Becker

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Articles 20
Citations 330
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Recent Articles
1.
Lantero-Rodriguez J, Camporesi E, Montoliu-Gaya L, Gobom J, Piotrowska D, Olsson M, et al.
Mol Neurodegener . 2024 Jul; 19(1):54. PMID: 39026372
Abnormal accumulation of misfolded and hyperphosphorylated tau protein in brain is the defining feature of several neurodegenerative diseases called tauopathies, including Alzheimer's disease (AD). In AD, this pathological change is...
2.
Islam T, Kvartsberg H, Sehrawat A, Kac P, Becker B, Olsson M, et al.
Alzheimers Dement . 2024 Mar; 20(4):2894-2905. PMID: 38520322
Introduction: Tau aggregation into paired helical filaments and neurofibrillary tangles is characteristic of Alzheimer's disease (AD) and related disorders. However, biochemical assays for the quantification of soluble, earlier-stage tau aggregates...
3.
Lantero-Rodriguez J, Montoliu-Gaya L, Benedet A, Vrillon A, Dumurgier J, Cognat E, et al.
Acta Neuropathol . 2024 Jan; 147(1):12. PMID: 38184490
Post-mortem staging of Alzheimer's disease (AD) neurofibrillary pathology is commonly performed by immunohistochemistry using AT8 antibody for phosphorylated tau (p-tau) at positions 202/205. Thus, quantification of p-tau205 and p-tau202 in...
4.
Weiner S, Sauer M, Brinkmalm G, Constantinescu J, Constantinescu R, Fernandes Gomes B, et al.
Alzheimers Dement . 2023 Mar; 19(10):4609-4618. PMID: 36946611
Introduction: Secernin-1 (SCRN1) is a neuronal protein that co-localizes with neurofibrillary tangles in Alzheimer's disease (AD), but not with tau inclusions in corticobasal degeneration (CBD), progressive supranuclear palsy (PSP), or...
5.
Meda F, Knowles K, Swift I, Sogorb-Esteve A, Rohrer J, Dittrich A, et al.
BMJ Neurol Open . 2023 Mar; 5(1):e000395. PMID: 36865081
Background: Neurofilament light (NfL) is a widely used biomarker for neurodegeneration. NfL is prone to oligomerisation, but available assays do not reveal the exact molecular nature of the protein variant...
6.
Camporesi E, Nilsson J, Vrillon A, Cognat E, Hourregue C, Zetterberg H, et al.
EBioMedicine . 2022 Jan; 75:103793. PMID: 34990894
Background: Synaptic proteins are increasingly studied as biomarkers for synaptic dysfunction and loss, which are early and central events in Alzheimer's disease (AD) and strongly correlate with the degree of...
7.
Camporesi E, Lashley T, Gobom J, Lantero-Rodriguez J, Hansson O, Zetterberg H, et al.
Acta Neuropathol Commun . 2021 Feb; 9(1):19. PMID: 33522967
Synaptic pathology is a central event in Alzheimer's disease (AD) and other neurodegenerative conditions, and investigation of synaptic proteins can provide valuable tools to follow synaptic dysfunction and loss in...
8.
Nazir F, Camporesi E, Brinkmalm G, Lashley T, Toomey C, Kvartsberg H, et al.
J Neurochem . 2020 Nov; 157(3):816-833. PMID: 33249594
Neurogranin (Ng) is a 78 amino acid neuronal protein and a biomarker candidate for Alzheimer's disease (AD). Ng has been suggested to bind to calmodulin and phosphatidic acid via its...
9.
Camporesi E, Nilsson J, Brinkmalm A, Becker B, Ashton N, Blennow K, et al.
Biomark Insights . 2020 Sep; 15:1177271920950319. PMID: 32913390
Synapses are the site for brain communication where information is transmitted between neurons and stored for memory formation. Synaptic degeneration is a global and early pathogenic event in neurodegenerative disorders...
10.
Karikari T, Keeling S, Hill E, Lantero Rodri Guez J, Nagel D, Becker B, et al.
ACS Chem Neurosci . 2020 Aug; 11(19):3117-3129. PMID: 32833429
Tau neurofibrillary tangles are key pathological features of Alzheimer's disease and other tauopathies. Recombinant protein technology is vital for studying the structure and function of tau in physiology and aggregation...