Bruck Taddese
Overview
Explore the profile of Bruck Taddese including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
448
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0
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Recent Articles
1.
Puszkarska A, Taddese B, Revell J, Davies G, Field J, Hornigold D, et al.
Nat Chem
. 2024 May;
16(9):1436-1444.
PMID: 38755312
Several peptide dual agonists of the human glucagon receptor (GCGR) and the glucagon-like peptide-1 receptor (GLP-1R) are in development for the treatment of type 2 diabetes, obesity and their associated...
2.
Schneider C, Buchanan A, Taddese B, Deane C
Bioinformatics
. 2021 Sep;
38(2):377-383.
PMID: 34546288
Motivation: Antibodies are one of the most important classes of pharmaceuticals, with over 80 approved molecules currently in use against a wide variety of diseases. The drug discovery process for...
3.
Taddese B, Garnier A, Deniaud M, Henrion D, Chabbert M
Bioinformatics
. 2021 Jan;
37(16):2483-2484.
PMID: 33471079
Summary: Both dynamic correlations in protein sidechain motions during molecular dynamics (MD) simulations and evolutionary correlations in multiple sequence alignments (MSAs) of homologous proteins may reveal functionally important residues. We...
4.
Wong W, Robinson S, Bujotzek A, Georges G, Lewis A, Shi J, et al.
MAbs
. 2021 Jan;
13(1):1873478.
PMID: 33448242
Solving the structure of an antibody-antigen complex gives atomic level information of the interactions between an antibody and its antigen, but such structures are expensive and hard to obtain. Alternative...
5.
Taddese B, Garnier A, Abdi H, Henrion D, Chabbert M
Sci Rep
. 2020 Sep;
10(1):15901.
PMID: 32985550
The dynamic structure of proteins is essential for their functions and may include large conformational transitions which can be studied by molecular dynamics (MD) simulations. However, details of these transitions...
6.
Raybould M, Marks C, Lewis A, Shi J, Bujotzek A, Taddese B, et al.
Nucleic Acids Res
. 2019 Sep;
48(D1):D383-D388.
PMID: 31555805
The Therapeutic Structural Antibody Database (Thera-SAbDab; http://opig.stats.ox.ac.uk/webapps/therasabdab) tracks all antibody- and nanobody-related therapeutics recognized by the World Health Organisation (WHO), and identifies any corresponding structures in the Structural Antibody Database...
7.
Williams W, Linley J, Jones C, Shibata Y, Snijder A, Button J, et al.
Pain
. 2019 May;
160(9):1989-2003.
PMID: 31045747
P2X4 is a ligand-gated ion channel implicated in neuropathic pain. Drug discovery efforts targeting P2X4 have been unsuccessful largely because of the difficulty in engineering specificity and selectivity. Here, we...
8.
Raybould M, Marks C, Krawczyk K, Taddese B, Nowak J, Lewis A, et al.
Proc Natl Acad Sci U S A
. 2019 Feb;
116(10):4025-4030.
PMID: 30765520
Therapeutic mAbs must not only bind to their target but must also be free from "developability issues" such as poor stability or high levels of aggregation. While small-molecule drug discovery...
9.
Wong W, Georges G, Ros F, Kelm S, Lewis A, Taddese B, et al.
Bioinformatics
. 2018 Oct;
35(10):1774-1776.
PMID: 30321295
Motivation: Canonical forms of the antibody complementarity-determining regions (CDRs) were first described in 1987 and have been redefined on multiple occasions since. The canonical forms are often used to approximate...
10.
Taddese B, Deniaud M, Garnier A, Tiss A, Guissouma H, Abdi H, et al.
PLoS Comput Biol
. 2018 Jun;
14(6):e1006209.
PMID: 29912865
Chemokines and their receptors (members of the GPCR super-family) are involved in a wide variety of physiological processes and diseases; thus, understanding the specificity of the chemokine receptor family could...