Bruce H Lipshutz
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Explore the profile of Bruce H Lipshutz including associated specialties, affiliations and a list of published articles.
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169
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1672
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Recent Articles
1.
Oftadeh E, Wong M, Yu J, Li X, Cao Y, Gallou F, et al.
J Org Chem
. 2024 Nov;
89(23):17331-17337.
PMID: 39526953
Environmentally respectful methods for generating and utilizing difluorocarbene (:CF) in the synthesis of a wide array of valuable difluoromethylated compounds are disclosed. In particular, the insertion of the CF moiety...
2.
Iyer K, Dismuke Rodriguez K, Lammert R, Yirak J, Saunders J, Kavthe R, et al.
Angew Chem Int Ed Engl
. 2024 Jul;
63(43):e202411295.
PMID: 39034288
Aryl fluorosulfates of varying complexities have been used in amination reactions in water using a new Pd oxidative addition complex (OAC-1) developed specifically to match the needs of the fine...
3.
Luescher M, Gallou F, Lipshutz B
Chem Sci
. 2024 Jun;
15(24):9016-9025.
PMID: 38903222
Substitution of one metal catalyst for another is not as straightforward as simply justifying this change based on the availability and/or cost of the metals. Methodologies to properly assess options...
4.
Caravez J, Hu Y, Oftadeh E, Mamo K, Lipshutz B
J Org Chem
. 2024 Mar;
89(6):3995-4000.
PMID: 38447077
A very efficient four-step synthesis of the main fragment of Gilead's anti-HIV drug lenacapavir is described. The route showcases a 1,2-addition to an intermediate aldehyde using an organozinc halide derived...
5.
Iyer K, Kavthe R, Lammert R, Yirak J, Lipshutz B
JACS Au
. 2024 Mar;
4(2):680-689.
PMID: 38425930
Sustainable technology for constructing Pd-catalyzed C-N bonds involving aliphatic amines is reported. A catalytic system that relies on , a known and , and a are combined, leading to a...
6.
Iyer K, Kavthe R, Hu Y, Lipshutz B
ACS Sustain Chem Eng
. 2024 Feb;
12(5):1997-2008.
PMID: 38333203
A general protocol employing heterogeneous catalysis has been developed that enables ppm of Pd-catalyzed C-N cross-coupling reactions under aqueous micellar catalysis. A new nanoparticle catalyst containing specifically ligated Pd, in...
7.
Thomas R, Obbard D, Lipshutz B
Chem Sci
. 2023 Nov;
14(46):13503-13507.
PMID: 38033910
Palladium-catalyzed reactions that involve functionalized substrates are oftentimes problematic. Those involving aryl or heteroaryl bromides that are either resistant to, or inefficient in such couplings present challenges that are difficult...
8.
Li X, Hu Y, Bailey J, Lipshutz B
Org Lett
. 2023 Oct;
26(14):2778-2783.
PMID: 37883080
The influence of added surfactant to aqueous reaction mixtures containing various IREDs has been determined. Just the presence of a nonionic surfactant tends to increase both rates and extent of...
9.
Kavthe R, Iyer K, Caravez J, Lipshutz B
Chem Sci
. 2023 Jun;
14(23):6399-6407.
PMID: 37325157
A 6-step synthesis of the antimalarial drug candidate MMV688533 is reported. Key transformations carried out under aqueous micellar conditions include two Sonogashira couplings and amide bond formation. Compared with the...
10.
Singhania V, Nelson C, Reamey M, Morin E, Kavthe R, Lipshutz B
Org Lett
. 2023 Jun;
25(23):4308-4312.
PMID: 37278485
Erdafitinib, an anticancer drug, was synthesized in a three-step two-pot sequence involving ppm levels of Pd catalyst run under aqueous micellar conditions enabled by a biodegradable surfactant. This process features...