Benjamin R Taft
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Explore the profile of Benjamin R Taft including associated specialties, affiliations and a list of published articles.
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17
Citations
180
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Recent Articles
1.
Taft B, Yokokawa F, Kirrane T, Mata A, Huang R, Blaquiere N, et al.
J Med Chem
. 2022 Mar;
65(5):3798-3813.
PMID: 35229610
A series of 5-aryl-2-amino-midazohiaiazole (ITD) derivatives were identified by a phenotype-based high-throughput screening using a blood stage () growth inhibition assay. A lead optimization program focused on improving antiplasmodium potency,...
2.
Trost B, Taft B, Tracy J, Stivala C
Org Lett
. 2021 Jun;
23(13):4981-4985.
PMID: 34114462
The synthesis of the pentacylic core of (+)-citrinadin A is described. Our strategy harnesses the power of palladium-catalyzed trimethylenemethane chemistry (Pd-TMM) to form the key spirooxindole motif in a catalytic,...
3.
Ramurthy S, Taft B, Aversa R, Barsanti P, Burger M, Lou Y, et al.
J Med Chem
. 2019 May;
63(5):2013-2027.
PMID: 31059256
Direct pharmacological inhibition of RAS has remained elusive, and efforts to target CRAF have been challenging due to the complex nature of RAF signaling, downstream of activated RAS, and the...
4.
Nishiguchi G, Rico A, Tanner H, Aversa R, Taft B, Subramanian S, et al.
J Med Chem
. 2017 May;
60(12):4869-4881.
PMID: 28557458
RAS oncogenes have been implicated in >30% of human cancers, all representing high unmet medical need. The exquisite dependency on CRAF kinase in KRAS mutant tumors has been established in...
5.
Trost B, Masters J, Taft B, Lumb J
Chem Sci
. 2016 Oct;
7(9):6217-6231.
PMID: 27746892
We present a full account detailing the development of a sequential catalysis strategy for the synthesis of chiral β-alkynyl carbonyl and sulfonyl derivatives. A palladium-catalyzed cross coupling of terminal alkyne...
6.
Lipshutz B, Isley N, Moser R, Ghorai S, Leuser H, Taft B
Adv Synth Catal
. 2014 Mar;
354(17):3175-3179.
PMID: 24659941
Using the newly introduced designer surfactant polyethyleneglycol ubiquinol sebacate (PQS), as the platform for micellar catalysis, nonracemic BINAP has been covalently attached and rhodium(I) inserted to form PQS-BINAP-Rh. This species,...
7.
Lipshutz B, Taft B, Abela A, Ghorai S, Krasovskiy A, Duplais C
Platin Met Rev
. 2013 Apr;
56(2):62-74.
PMID: 23555153
Palladium-catalysed cross-couplings, in particular Heck, Suzuki-Miyaura and Negishi reactions developed over three decades ago, are routinely carried out in organic solvents. However, alternative media are currently of considerable interest given...
8.
Trost B, Taft B, Masters J, Lumb J
J Am Chem Soc
. 2011 May;
133(22):8502-5.
PMID: 21557627
A new strategy for the synthesis of chiral β-alkynyl esters which relies on sequential Pd and Cu catalysis is reported. Terminal alkynes bearing aryl, alkyl, and silyl groups can be...
9.
Lipshutz B, Ghorai S, Leong W, Taft B, Krogstad D
J Org Chem
. 2011 May;
76(12):5061-73.
PMID: 21539384
The remarkable effects of added salts on the properties of aqueous micelles derived from the amphiphile PTS are described. Most notably, Heck reactions run in the presence of NaCl lead...
10.
Gallagher B, Taft B, Lipshutz B
Org Lett
. 2009 Nov;
11(23):5374-7.
PMID: 19877705
The combination of catalytic amounts of [(R)-DTBM-SEGPHOS]CuH in the presence of stoichiometric DEMS (diethoxymethylsilane) in toluene at room temperature leads to asymmetric reductions of 4-substituted coumarins. Several targets or their...