Bruce C Kone
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Explore the profile of Bruce C Kone including associated specialties, affiliations and a list of published articles.
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51
Citations
1124
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Recent Articles
1.
Yu Z, Kong Q, Kone B
Biosci Rep
. 2013 Sep;
33(5).
PMID: 24070375
The physical and functional interaction of Rnf2 (RING finger protein 2), a central component of the PRC (Polycomb repressive complex) 1 and Af9 (ALL1-fused gene from chromosome 9 protein), an...
2.
Kone B
Semin Nephrol
. 2013 Sep;
33(4):383-91.
PMID: 24011580
The apical membrane epithelial Na(+) channel subunit (ENaC) in series with the basolateral Na(+)/K(+)-adenosine triphosphatase mediates collecting duct Na(+) reabsorption. Aldosterone induces αENaC gene transcription, which appears to be rate...
3.
Yu Z, Kong Q, Kone B
Am J Physiol Renal Physiol
. 2013 Aug;
305(7):F1006-13.
PMID: 23926181
Aldosterone increases tubular Na(+) absorption largely by increasing α-epithelial Na(+) channel (αENaC) transcription in collecting duct principal cells. How aldosterone reprograms basal αENaC transcription to high-level activity in the collecting...
4.
Yu Z, Kong Q, Kone B
Am J Physiol Renal Physiol
. 2013 Jun;
305(5):F653-62.
PMID: 23804453
The epithelial Na+ channel (ENaC) in the distal nephron constitutes the rate-limiting step for renal sodium reabsorption. Aldosterone increases tubular sodium absorption in large part by increasing αENaC transcription in...
5.
Singh R, Kone B, Gounni A, Uzonna J
PLoS One
. 2013 Mar;
8(3):e59631.
PMID: 23536884
BALB/c mice are highly susceptible while C57BL/6 mice are relatively resistant to experimental Trypanosoma congolense infection. Several reports show that an early interferon-gamma (IFN-γ) response in infected mice is critically...
6.
Zhang W, Yu Z, Wu H, Chen L, Kong Q, Kone B
Am J Physiol Renal Physiol
. 2012 Nov;
304(4):F367-75.
PMID: 23152297
The epithelial Na(+) channel subunit-α (αENaC) of the distal nephron is essential for salt balance. We previously demonstrated that the histone methyltransferase Dot1a and its protein partner Af9 basally repress...
7.
Duarte J, Zineh I, Burkley B, Gong Y, Langaee T, Turner S, et al.
J Transl Med
. 2012 Mar;
10:56.
PMID: 22440088
Background: Nearly one-third of the United States adult population suffers from hypertension. Hydrochlorothiazide (HCTZ), one of the most commonly used medications to treat hypertension, has variable efficacy. The renal epithelial...
8.
Yu Z, Kong Q, Kone B
Am J Physiol Renal Physiol
. 2010 Jan;
298(3):F617-24.
PMID: 20053791
Connective tissue growth factor (CTGF) participates in diverse fibrotic processes including glomerulosclerosis. The adenylyl cyclase agonist forskolin inhibits CTGF expression in mesangial cells by unclear mechanisms. We recently reported that...
9.
Reisenauer M, Anderson M, Huang L, Zhang Z, Zhou Q, Kone B, et al.
J Biol Chem
. 2009 Oct;
284(51):35659-69.
PMID: 19864429
We previously reported that Dot1a.AF9 complex represses transcription of the epithelial Na(+) channel subunit alpha (alpha-ENaC) gene in mouse inner medullary collecting duct mIMCD3 cells and mouse kidney. Aldosterone relieves...
10.
Moore-Olufemi S, Olufemi S, Lott S, Sato N, Kozar R, Moore F, et al.
Dig Dis Sci
. 2009 Sep;
55(7):1866-77.
PMID: 19779973
Objective: Intestinal ischemia/reperfusion (IR) injury involves activation of inflammatory mediators, mucosal necrosis, ileus, and alteration in a variety of gene products. Ischemic preconditioning (IPC) reduced all the effects of intestinal...