Brock C Christensen
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Explore the profile of Brock C Christensen including associated specialties, affiliations and a list of published articles.
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187
Citations
6875
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Recent Articles
1.
Kucharski T, Vlasac I, Lyalina T, Higgs M, Christensen B, Bechstedt S, et al.
Cell Rep
. 2025 Feb;
44(2):115317.
PMID: 39970043
Cancer cells are often aneuploid and frequently display elevated rates of chromosome mis-segregation, called chromosomal instability (CIN). CIN is caused by hyperstable kinetochore-microtubule (K-MT) attachments that reduce the correction efficiency...
2.
Muse M, Wang Y, Gilbert-Diamond D, Armstrong D, Hoen A, Romano M, et al.
Eur J Nutr
. 2025 Feb;
64(2):75.
PMID: 39891736
Purpose: During pregnancy, extracellular vesicle and particle microRNAs (EVP miRNA) in maternal circulation have the capacity to cross the placenta and facilitate maternal-fetal communication. Both dysregulation of circulating EVP miRNA...
3.
Vlasac I, Stolrow H, Thayer Z, Christensen B, Rivera L
Epigenetics
. 2025 Jan;
20(1):2453275.
PMID: 39825876
Menstrual effluent cell profiles have potential as noninvasive biomarkers of female reproductive and gynecological health and disease. We used DNA methylation-based cell type deconvolution (methylation cytometry) to identify cell type...
4.
Chen Y, Salas L, Marotti J, Jenkins N, Cheng C, Miller T, et al.
Int J Cancer
. 2024 Dec;
156(6):1191-1202.
PMID: 39635770
Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype with substantial disease heterogeneity, limited treatment options, and dismal clinical outcomes. Some TNBCs display homologous recombination deficiency (HRD), a...
5.
Levy J, Diallo A, Saldias Montivero M, Gabbita S, Salas L, Christensen B
Epigenomics
. 2024 Nov;
17(1):49-57.
PMID: 39584810
Over the past century, human lifespan has increased remarkably, yet the inevitability of aging persists. The disparity between biological age, which reflects pathological deterioration and disease, and chronological age, indicative...
6.
Zhang Z, Sehgal K, Shirai K, Butler R, Wiencke J, Koestler D, et al.
NPJ Precis Oncol
. 2024 Nov;
8(1):267.
PMID: 39558036
Tissue biomarkers for immune checkpoint inhibitor (ICI) response are limited by tumor sample heterogeneity and availability. This study identifies clinically actionable pretreatment blood biomarkers that are associated with ICI treatment...
7.
Criswell R, Bauer J, Christensen B, Meijer J, Peterson L, Huset C, et al.
Environ Epidemiol
. 2024 Oct;
8(6):e352.
PMID: 39474471
Background: Per- and polyfluoroalkyl substances (PFAS) are a class of persistent synthetic chemicals that are found in human milk and are associated with negative health effects. Research suggests that PFAS...
8.
Pike S, Wiencke J, Zhang Z, Molinaro A, Hansen H, Koestler D, et al.
Acta Neuropathol Commun
. 2024 Oct;
12(1):170.
PMID: 39468647
A scalable platform for cell typing in the glioma microenvironment can improve tumor subtyping and immune landscape detection as successful immunotherapy strategies continue to be sought and evaluated. DNA methylation...
9.
Fatemi M, Lu Y, Diallo A, Srinivasan G, Azher Z, Christensen B, et al.
Brief Bioinform
. 2024 Oct;
25(6).
PMID: 39367648
The application of deep learning to spatial transcriptomics (ST) can reveal relationships between gene expression and tissue architecture. Prior work has demonstrated that inferring gene expression from tissue histomorphology can...
10.
Alsup A, Nissen E, Salas L, Molinaro A, Reiner A, Liu S, et al.
Epigenomics
. 2024 Aug;
16(15-16):1067-1080.
PMID: 39093129
DNA methylation (DNAm)-based deconvolution estimates contain relative data, forming a composition, that standard methods (testing directly on cell proportions) are ill-suited to handle. In this study we examined the performance...