Devin C Koestler
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Explore the profile of Devin C Koestler including associated specialties, affiliations and a list of published articles.
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153
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5282
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Recent Articles
1.
Jones M, Konwar C, Asiimwe R, Dinh L, Razzaghian H, de Goede O, et al.
Commun Biol
. 2025 Feb;
8(1):237.
PMID: 39953282
Epigenetic modifications such as DNA methylation are both cell type and developmental age specific. Here, we show that the immunological maturation of blood cell types influences DNA methylation changes from...
2.
Ngo L, Rekowski M, Koestler D, Yorozuya T, Saito A, Azeem I, et al.
ERJ Open Res
. 2024 Dec;
10(6.
PMID: 39687393
Background: Idiopathic interstitial pneumonias (IIPs), such as idiopathic pulmonary fibrosis and interstitial pneumonia with autoimmune features, present diagnostic and therapeutic challenges due to their heterogeneous nature. This study aimed to...
3.
Zhang Z, Sehgal K, Shirai K, Butler R, Wiencke J, Koestler D, et al.
NPJ Precis Oncol
. 2024 Nov;
8(1):267.
PMID: 39558036
Tissue biomarkers for immune checkpoint inhibitor (ICI) response are limited by tumor sample heterogeneity and availability. This study identifies clinically actionable pretreatment blood biomarkers that are associated with ICI treatment...
4.
Ru M, Michaud D, Zhao N, Kelsey K, Koestler D, Lu J, et al.
Environ Epigenet
. 2024 Nov;
10(1):dvae015.
PMID: 39544416
A prior study reported no association between prenatal smoking methylation scores and adult lung cancer risk adjusting for methylation-predicted adult smoking, without considering maternal smoking trends by birth cohort. To...
5.
Pike S, Wiencke J, Zhang Z, Molinaro A, Hansen H, Koestler D, et al.
Acta Neuropathol Commun
. 2024 Oct;
12(1):170.
PMID: 39468647
A scalable platform for cell typing in the glioma microenvironment can improve tumor subtyping and immune landscape detection as successful immunotherapy strategies continue to be sought and evaluated. DNA methylation...
6.
Semancik C, Zhao N, Koestler D, Boerwinkle E, Bressler J, Buchsbaum R, et al.
Cancer Res Commun
. 2024 Sep;
4(10):2714-2723.
PMID: 39324671
This study describes associations between immune cell types and cancer risk in a Black population; elevated regulatory T-cell proportions that were associated with increased overall cancer and lung cancer risk,...
7.
Alsup A, Nissen E, Salas L, Molinaro A, Reiner A, Liu S, et al.
Epigenomics
. 2024 Aug;
16(15-16):1067-1080.
PMID: 39093129
DNA methylation (DNAm)-based deconvolution estimates contain relative data, forming a composition, that standard methods (testing directly on cell proportions) are ill-suited to handle. In this study we examined the performance...
8.
Lee M, Zhang Z, Sehgal K, Butler R, Stolrow H, Ramush G, et al.
Epigenomics
. 2024 Jun;
16(11-12):799-807.
PMID: 38869472
This study addresses the challenge of predicting the response of head and neck squamous cell carcinoma (HNSCC) patients to immunotherapy. Using DNA methylation cytometry, we analyzed the immune profiles of...
9.
Ngo L, Rekowski M, Koestler D, Yorozuya T, Saito A, Azeem I, et al.
medRxiv
. 2024 Jun;
PMID: 38853991
Background: Idiopathic interstitial pneumonias (IIPs) such as idiopathic pulmonary fibrosis (IPF) and interstitial pneumonia with autoimmune features (IPAF), present diagnostic and therapeutic challenges due to their heterogeneous nature. This study...
10.
Semancik C, Zhao N, Koestler D, Boerwinkle E, Bressler J, Buchsbaum R, et al.
medRxiv
. 2024 May;
PMID: 38766207
Prior cohort studies assessing cancer risk based on immune cell subtype profiles have predominantly focused on White populations. This limitation obscures vital insights into how cancer risk varies across race....