Brittany Cain
Overview
Explore the profile of Brittany Cain including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
52
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Recent Articles
1.
Tweedie L, Tweedie L, Riccetti M, Riccetti M, Cain B, Cain B, et al.
Dis Model Mech
. 2025 Jan;
18(2).
PMID: 39882631
Gsx2 is a homeodomain transcription factor critical for development of the ventral telencephalon and hindbrain in mouse. Loss of Gsx2 function results in severe basal ganglia dysgenesis and defects in...
2.
Webb J, Farrow E, Cain B, Yuan Z, Yarawsky A, Schoch E, et al.
Nucleic Acids Res
. 2024 Jun;
52(13):7987-8002.
PMID: 38874471
The conserved Gsx homeodomain (HD) transcription factors specify neural cell fates in animals from flies to mammals. Like many HD proteins, Gsx factors bind A/T-rich DNA sequences prompting the following...
3.
Webb J, Farrow E, Cain B, Yuan Z, Yarawsky A, Schoch E, et al.
bioRxiv
. 2023 Dec;
PMID: 38106145
The conserved Gsx homeodomain (HD) transcription factors specify neural cell fates in animals from flies to mammals. Like many HD proteins, Gsx factors bind A/T-rich DNA sequences prompting the question...
4.
Cain B, Webb J, Yuan Z, Cheung D, Lim H, Kovall R, et al.
Nucleic Acids Res
. 2023 Apr;
51(12):6055-6072.
PMID: 37114997
Homeodomain proteins constitute one of the largest families of metazoan transcription factors. Genetic studies have demonstrated that homeodomain proteins regulate many developmental processes. Yet, biochemical data reveal that most bind...
5.
Cain B, Gebelein B
Front Cell Dev Biol
. 2021 Dec;
9:787339.
PMID: 34869389
Metazoans differentially express multiple Hox transcription factors to specify diverse cell fates along the developing anterior-posterior axis. Two challenges arise when trying to understand how the Hox transcription factors regulate...
6.
Kuang Y, Pyo A, Eafergan N, Cain B, Gutzwiller L, Axelrod O, et al.
PLoS Genet
. 2021 Sep;
17(9):e1009039.
PMID: 34559800
Notch signaling controls many developmental processes by regulating gene expression. Notch-dependent enhancers recruit activation complexes consisting of the Notch intracellular domain, the Cbf/Su(H)/Lag1 (CSL) transcription factor (TF), and the Mastermind...
7.
Salomone J, Qin S, Fufa T, Cain B, Farrow E, Guan B, et al.
Genes Dev
. 2020 Dec;
35(1-2):157-174.
PMID: 33334823
How homeodomain proteins gain sufficient specificity to control different cell fates has been a long-standing problem in developmental biology. The conserved Gsx homeodomain proteins regulate specific aspects of neural development...
8.
Kuang Y, Golan O, Preusse K, Cain B, Christensen C, Salomone J, et al.
Elife
. 2020 Apr;
9.
PMID: 32297857
Notch pathway haploinsufficiency can cause severe developmental syndromes with highly variable penetrance. Currently, we have a limited mechanistic understanding of phenotype variability due to gene dosage. Here, we unexpectedly found...
9.
Roychoudhury K, Salomone J, Qin S, Cain B, Adam M, Potter S, et al.
Development
. 2020 Mar;
147(7).
PMID: 32122989
The Gsx2 homeodomain transcription factor promotes neural progenitor identity in the lateral ganglionic eminence (LGE), despite upregulating the neurogenic factor Ascl1. How this balance in maturation is maintained is unclear....