Brian Y Feng
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Explore the profile of Brian Y Feng including associated specialties, affiliations and a list of published articles.
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716
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Recent Articles
1.
Ooi J, Fairhall J, Spangler B, Chong D, Feng B, Gamble A, et al.
RSC Adv
. 2022 Jun;
12(25):15631-15642.
PMID: 35685699
Bioorthogonal chemistry can facilitate the development of fluorescent probes that can be used to sensitively and specifically detect the presence of biological targets. In this study, such an assay was...
2.
Coram M, Wang L, Godinez W, Barkan D, Armstrong Z, Ando D, et al.
ACS Infect Dis
. 2021 Dec;
8(1):66-77.
PMID: 34937332
Combination therapies are common in many therapeutic contexts, including infectious diseases and cancer. A common approach for evaluating combinations is to assess effects on cell growth as synergistic, antagonistic, or...
3.
Godinez W, Chan H, Hossain I, Li C, Ranjitkar S, Rasper D, et al.
ACS Chem Biol
. 2019 Jun;
14(6):1217-1226.
PMID: 31184469
Beta-lactams comprise one of the earliest classes of antibiotic therapies. These molecules covalently inhibit enzymes from the family of penicillin-binding proteins (PBPs), which are essential in construction of the bacterial...
4.
Spangler B, Yang S, Baxter Rath C, Reck F, Feng B
ACS Chem Biol
. 2019 Mar;
14(4):725-734.
PMID: 30908011
Compartmentalization is a crucial facet of many biological systems, and key aspects of cellular processes rely on spatial segregation within the cell. While many drug targets reside in specific intracellular...
5.
Spangler B, Dovala D, Sawyer W, Thompson K, Six D, Reck F, et al.
ACS Infect Dis
. 2018 May;
4(9):1355-1367.
PMID: 29846057
The Gram-negative cell envelope presents a formidable barrier to xenobiotics, and achieving sufficient compound exposure inside the cell is a key challenge for the discovery of new antibiotics. To provide...
6.
Skepper C, Moreau R, Appleton B, Benton B, Drumm 3rd J, Feng B, et al.
J Med Chem
. 2018 Mar;
61(8):3325-3349.
PMID: 29551072
In the preceding manuscript [ Moreau et al. 2018 , 10.1021/acs.jmedchem.7b01691 ] we described a successful fragment-based lead discovery (FBLD) strategy for discovery of bacterial phosphopantetheine adenylyltransferase inhibitors (PPAT, CoaD)....
7.
Moreau R, Skepper C, Appleton B, Blechschmidt A, Balibar C, Benton B, et al.
J Med Chem
. 2018 Mar;
61(8):3309-3324.
PMID: 29498517
The discovery and development of new antibiotics capable of curing infections due to multidrug-resistant and pandrug-resistant Gram-negative bacteria are a major challenge with fundamental importance to our global healthcare system....
8.
Rath C, Benton B, De Vicente J, Drumm J, Geng M, Li C, et al.
ACS Infect Dis
. 2017 Dec;
4(3):391-402.
PMID: 29243909
Drug-resistant Gram-negative bacteria are of increasing concern worldwide. Novel antibiotics are needed, but their development is complicated by the requirement to simultaneously optimize molecules for target affinity and cellular potency,...
9.
Hillman R, Feng B, Ni J, Woo W, Milenkovic L, Hayden Gephart M, et al.
Genes Dev
. 2011 Nov;
25(22):2333-46.
PMID: 22051878
The Hedgehog (Hh) pathway is essential for vertebrate embryogenesis, and excessive Hh target gene activation can cause cancer in humans. Here we show that Neuropilin 1 (Nrp1) and Nrp2, transmembrane...
10.
Feng B, Toyama B, Wille H, Colby D, Collins S, May B, et al.
Nat Chem Biol
. 2008 Jan;
4(3):197-9.
PMID: 18223646
Many amyloid inhibitors resemble molecules that form chemical aggregates, which are known to inhibit many proteins. Eight known chemical aggregators inhibited amyloid formation of the yeast and mouse prion proteins...