Brian Westwood
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Explore the profile of Brian Westwood including associated specialties, affiliations and a list of published articles.
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12
Citations
109
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Recent Articles
1.
Arnone A, Tsai Y, Cline J, Wilson A, Westwood B, Seger M, et al.
Cell Rep Med
. 2025 Jan;
6(1):101880.
PMID: 39742868
Studies indicate that breast tissue has a distinct modifiable microbiome population. We demonstrate that endocrine-targeting therapies, such as tamoxifen, reshape the non-cancerous breast microbiome to influence tissue metabolism and reduce...
2.
Elsangeedy E, Yamaleyeva D, Edenhoffer N, Deak A, Soloshenko A, Ray J, et al.
NPJ Microgravity
. 2024 Dec;
10(1):110.
PMID: 39702444
Men and women have different cardiovascular responses to spaceflight; however, few studies have focused on direct comparisons between sexes. We investigated the mechanisms of aortic stiffening in socially and sexually...
3.
A Novel Metastatic Estrogen Receptor-Expressing Breast Cancer Model with Antiestrogen Responsiveness
Langsten K, Shi L, Wilson A, Lumia S, Westwood B, Skeen A, et al.
Cancers (Basel)
. 2023 Dec;
15(24).
PMID: 38136319
Most women diagnosed with breast cancer (BC) have estrogen receptor alpha-positive (ER+) disease. The current mouse models of ER+ BC often rely on exogenous estrogen to encourage metastasis, which modifies...
4.
Mackert J, Stirling E, Wilson A, Westwood B, Zhao D, Lo H, et al.
bioRxiv
. 2023 Aug;
PMID: 37546807
The presence of cell surface protein CD47 allows cancer cells to evade innate and adaptive immune surveillance resulting in metastatic spread. CD47 binds to and activates SIRPα on the surface...
5.
Bronson S, Westwood B, Cook K, Emenaker N, Chappell M, Roberts D, et al.
Metabolites
. 2022 Nov;
12(11).
PMID: 36355119
Thrombospondin-1 (TSP1) is a matricellular protein with many important roles in mediating carcinogenesis, fibrosis, leukocyte recruitment, and metabolism. We have previously shown a role of diet in the absence of...
6.
Rahimi O, Melo A, Westwood B, Grier R, Tallant E, Gallagher P
Peptides
. 2022 Mar;
152:170784.
PMID: 35288251
Doxorubicin (Dox), an effective chemotherapeutic, can cause cumulative dose-dependent cardiovascular toxicity, which may manifest as vascular dysfunction leading to long-term end-organ damage. Currently, there are no effective treatments to mitigate...
7.
Triozzi P, Stirling E, Song Q, Westwood B, Kooshki M, Forbes M, et al.
Clin Cancer Res
. 2022 Mar;
28(6):1192-1202.
PMID: 35284940
Purpose: Immunotherapy with checkpoint inhibitors is improving the outcomes of several cancers. However, only a subset of patients respond. Therefore, predictive biomarkers are critically needed to guide treatment decisions and...
8.
Skeletal muscle extracellular matrix remodeling with worsening glycemic control in nonhuman primates
Ruggiero A, Davis A, Sherrill C, Westwood B, Hawkins G, Palmer N, et al.
Am J Physiol Regul Integr Comp Physiol
. 2020 Nov;
320(3):R226-R235.
PMID: 33206559
Type 2 diabetes (T2D) development may be mediated by skeletal muscle (SkM) function, which is responsible for >80% of circulating glucose uptake. The goals of this study were to assess...
9.
Brosnihan K, Merrill D, Yamaleyeva L, Chen K, Neves L, Joyner J, et al.
Endocrine
. 2020 Apr;
69(2):410-419.
PMID: 32319014
Purpose: To address whether differential regulation of the renin-angiotensin-aldosterone system occurs in pre-eclampsia, we performed an analysis of the time course of circulating and urinary profiles of the vasoconstrictor (Ang...
10.
Rahimi O, Kirby J, Varagic J, Westwood B, Tallant E, Gallagher P
Am J Physiol Heart Circ Physiol
. 2020 Feb;
318(4):H883-H894.
PMID: 32083974
Doxorubicin (Dox) is an effective chemotherapeutic for a variety of pediatric malignancies. Unfortunately, Dox administration often results in a cumulative dose-dependent cardiotoxicity that manifests with marked oxidative stress, leading to...