Brian Tjaden
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Explore the profile of Brian Tjaden including associated specialties, affiliations and a list of published articles.
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29
Citations
1383
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Recent Articles
1.
Tjaden B
Genome Biol
. 2023 Dec;
24(1):276.
PMID: 38041165
Small regulatory RNAs pervade prokaryotes, with the best-studied family of these non-coding genes corresponding to trans-acting regulators that bind via base pairing to their message targets. Given the increasing frequency...
2.
Tjaden J, Tjaden B
PLoS One
. 2023 Nov;
18(11):e0294924.
PMID: 38032968
The democratization of machine learning is a popular and growing movement. In a world with a wealth of publicly available data, it is important that algorithms for analysis of data...
3.
Tjaden B
RNA Biol
. 2023 Mar;
20(1):77-84.
PMID: 36920168
Owing to the complexities of bacterial RNA biology, the transcriptomes of even the best studied bacteria are not fully understood. To help elucidate the transcriptional landscape of , we compiled...
4.
Jagodnik J, Tjaden B, Ross W, Gourse R
Nucleic Acids Res
. 2023 Jan;
51(2):852-869.
PMID: 36617997
Ligand-binding RNAs (RNA aptamers) are widespread in the three domains of life, serving as sensors of metabolites and other small molecules. When aptamers are embedded within RNA transcripts as components...
5.
Tjaden B
Methods
. 2019 Apr;
176:62-70.
PMID: 30953757
An operon is a set of neighboring genes in a genome that is transcribed as a single polycistronic message. Genes that are part of the same operon often have related...
6.
Nudel K, McClure R, Moreau M, Briars E, Abrams A, Tjaden B, et al.
mSphere
. 2018 Jun;
3(3).
PMID: 29950382
is a bacterial pathogen responsible for the sexually transmitted infection gonorrhea. Emergence of antimicrobial resistance (AMR) of worldwide has resulted in limited therapeutic choices for this infection. Men who seek...
7.
Gerrick E, Barbier T, Chase M, Xu R, Francois J, Lin V, et al.
Proc Natl Acad Sci U S A
. 2018 Jun;
115(25):6464-6469.
PMID: 29871950
One key to the success of as a pathogen is its ability to reside in the hostile environment of the human macrophage. Bacteria adapt to stress through a variety of...
8.
Calfee G, Danger J, Jain I, Miller E, Sarkar P, Tjaden B, et al.
Infect Immun
. 2017 Nov;
86(2).
PMID: 29158432
Isolates of a given bacterial pathogen often display phenotypic variation, and this can negatively impact public health, for example, by reducing the efficacy of preventative measures. Here, we identify that...
9.
Zhang Y, Han K, Chandler C, Tjaden B, Ernst R, Lory S
Mol Microbiol
. 2017 Oct;
106(6):919-937.
PMID: 28976035
During environmental adaptation bacteria use small regulatory RNAs (sRNAs) to repress or activate expression of a large fraction of their proteome. We extended the use of the in vivo RNA...
10.
Han K, Tjaden B, Lory S
Nat Microbiol
. 2016 Dec;
2:16239.
PMID: 28005055
The first step in the post-transcriptional regulatory function of most bacterial small non-coding RNAs (sRNAs) is base pairing with partially complementary sequences of targeted transcripts. We present a simple method...