Brian T Wilhelm
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Explore the profile of Brian T Wilhelm including associated specialties, affiliations and a list of published articles.
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41
Citations
1622
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Recent Articles
1.
Safa-Tahar-Henni S, Paez Martinez K, Gress V, Esparza N, Roques E, Bonnet-Magnaval F, et al.
Leukemia
. 2024 Oct;
39(1):29-41.
PMID: 39472547
Targeted therapeutics for high-risk cancers remain an unmet medical need. Here we report the results of a large-scale screen of over 11,000 molecules for their ability to inhibit the survival...
2.
Gress V, Roussy M, Boulianne L, Bilodeau M, Cardin S, El-Hachem N, et al.
Blood Adv
. 2023 Sep;
8(1):112-129.
PMID: 37729615
Acute megakaryoblastic leukemia (AMKL) is a rare, developmentally restricted, and highly lethal cancer of early childhood. The paucity and hypocellularity (due to myelofibrosis) of primary patient samples hamper the discovery...
3.
Denford S, Wilhelm B
Front Oncol
. 2023 Jul;
13:1211540.
PMID: 37456227
Methyltransferases are enzymes fundamental to a wide range of normal biological activities that can become dysregulated during oncogenesis. For instance, the recent description of the methyltransferase-like (METTL) family of enzymes,...
4.
Milan T, Celton M, Lagace K, Roques E, Safa-Tahar-Henni S, Bresson E, et al.
Haematologica
. 2020 Dec;
107(1):86-99.
PMID: 33375773
Chromosomal translocations involving KMT2A gene are one of the most common genetic alterations found in pediatric acute myeloid leukemias (AML) although the molecular mechanisms that initiate the disease remain incompletely...
5.
Bulaeva E, Pellacani D, Nakamichi N, Hammond C, Beer P, Lorzadeh A, et al.
Blood
. 2020 Dec;
136(24):2764-2773.
PMID: 33301029
Hematopoietic clones with leukemogenic mutations arise in healthy people as they age, but progression to acute myeloid leukemia (AML) is rare. Recent evidence suggests that the microenvironment may play an...
6.
Cardin S, Bilodeau M, Roussy M, Aubert L, Milan T, Jouan L, et al.
Blood Adv
. 2019 Nov;
3(21):3307-3321.
PMID: 31698461
Acute megakaryoblastic leukemia (AMKL) represents ∼10% of pediatric acute myeloid leukemia cases and typically affects young children (<3 years of age). It remains plagued with extremely poor treatment outcomes (<40%...
7.
Pincez T, Landry J, Roussy M, Jouan L, Bilodeau M, Laramee L, et al.
Genes Chromosomes Cancer
. 2019 Sep;
59(2):125-130.
PMID: 31515871
Infant acute lymphoblastic leukemias (ALL) are rare hematological malignancies occurring in children younger than 1 year of age, most frequently associated with KMT2A rearrangements (KMT2A-r). The smaller subset without KMT2A-r,...
8.
Milan T, Canaj H, Villeneuve C, Ghosh A, Barabe F, Cellot S, et al.
Exp Hematol
. 2019 Jun;
74:1-12.
PMID: 31154068
Leukemia is a complex genetic disease caused by errors in differentiation, growth, and apoptosis of hematopoietic cells in either lymphoid or myeloid lineages. Large-scale genomic characterization of thousands of leukemia...
9.
Roussy M, Bilodeau M, Jouan L, Tibout P, Laramee L, Lemyre E, et al.
Genes Chromosomes Cancer
. 2018 Feb;
57(6):311-319.
PMID: 29427526
The advent of large scale genomic sequencing technologies significantly improved the molecular classification of acute megakaryoblastic leukaemia (AMKL). AMKL represents a subset (∼10%) of high fatality pediatric acute myeloid leukemia...
10.
Cellot S, Wilhelm B, Barabe F
Oncotarget
. 2017 Dec;
8(57):96480-96481.
PMID: 29228546
No abstract available.