Brian Sproat
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Explore the profile of Brian Sproat including associated specialties, affiliations and a list of published articles.
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11
Citations
272
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Recent Articles
1.
Darniot M, Schildgen V, Schildgen O, Sproat B, Kleines M, Ditt V, et al.
Antiviral Res
. 2012 Jan;
93(3):364-73.
PMID: 22285728
Human metapneumovirus causes respiratory diseases with outcomes that can be severe in children, the immunocompromised, and the elderly. Synthetic small interfering RNAs (siRNAs) that silence targeted genes can be used...
2.
Vendeix F, Murphy 4th F, Cantara W, Leszczynska G, Gustilo E, Sproat B, et al.
J Mol Biol
. 2012 Jan;
416(4):467-85.
PMID: 22227389
Human tRNA(Lys3)(UUU) (htRNA(Lys3)(UUU)) decodes the lysine codons AAA and AAG during translation and also plays a crucial role as the primer for HIV-1 (human immunodeficiency virus type 1) reverse transcription....
3.
Graham W, Barley-Maloney L, Stark C, Kaur A, Stolarchuk C, Stolyarchuk K, et al.
J Mol Biol
. 2011 Jul;
410(4):698-715.
PMID: 21762809
The HIV-1 nucleocapsid protein, NCp7, facilitates the use of human tRNA(Lys3)(UUU) as the primer for reverse transcription. NCp7 also remodels the htRNA's amino acid accepting stem and anticodon domains in...
4.
Liu Y, Samsonova O, Sproat B, Merkel O, Kissel T
J Control Release
. 2011 May;
153(3):262-8.
PMID: 21549166
A library of mono-methoxyl-poly(ethylene glycol)-block-poly(ε-caprolactone) (mPEG-PCL) modified hyperbranched PEI copolymers (hy-PEI-PCL-mPEG) was synthesized to establish structure function relationships for siRNA delivery. These amphiphilic block-copolymers were thought to provide improved colloidal...
5.
Moore M, Cookson J, Coventry V, Sproat B, Rabe L, Cranston R, et al.
J Biol Chem
. 2010 Nov;
286(4):2526-35.
PMID: 21106536
RNA-based drugs are an emerging class of therapeutics. They have the potential to regulate proteins, chromatin, as well as bind to specific proteins of interest in the form of aptamers....
6.
Merkel O, Mintzer M, Librizzi D, Samsonova O, Dicke T, Sproat B, et al.
Mol Pharm
. 2010 Jun;
7(4):969-83.
PMID: 20524664
A family of triazine dendrimers, differing in their core flexibility, generation number, and surface functionality, was prepared and evaluated for its ability to accomplish RNAi. The dendriplexes were analyzed with...
7.
Merkel O, Beyerle A, Librizzi D, Pfestroff A, Behr T, Sproat B, et al.
Mol Pharm
. 2009 Jul;
6(4):1246-60.
PMID: 19606864
This study describes the physicobiological characterization of PEI- and PEG-PEI polyplexes containing partially 2'-OMe modified 25/27mer dicer substrate siRNAs (DsiRNAs) and their in vivo behavior regarding biodistribution and systemic bioavailability...
8.
Cohen C, Forzan M, Sproat B, Pantophlet R, McGowan I, Burton D, et al.
Virology
. 2008 Sep;
381(1):46-54.
PMID: 18799178
We have previously isolated nucleic acid ligands (aptamers) that bind the surface envelope glycoprotein, gp120, of HIV-1, and neutralize infection of diverse sub-types of virus. Our earlier studies have identified...
9.
Vendeix F, Dziergowska A, Gustilo E, Graham W, Sproat B, Malkiewicz A, et al.
Biochemistry
. 2008 May;
47(23):6117-29.
PMID: 18473483
The accuracy and efficiency with which tRNA decodes genomic information into proteins require posttranscriptional modifications in or adjacent to the anticodon. The modification uridine-5-oxyacetic acid (cmo (5)U 34) is found...
10.
Van de Vijver P, Ostrowski T, Sproat B, Goebels J, Rutgeerts O, Van Aerschot A, et al.
J Med Chem
. 2008 Apr;
51(10):3020-9.
PMID: 18438987
The aminoacyl-tRNA synthetase family of enzymes is the target of many antibacterials and inhibitors of eukaryotic hyperproliferation. In screening analogues of 5'-O-(N-L-aminoacyl)-sulfamoyladenosine containing all 20 proteinogenic amino acids, we found...