Brian Monks
Overview
Explore the profile of Brian Monks including associated specialties, affiliations and a list of published articles.
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12
Citations
1476
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Recent Articles
1.
Mansouri M, DeStefano K, Monks B, Singh J, McDonnold M, Morgan J, et al.
AJP Rep
. 2017 Nov;
7(4):e211-e214.
PMID: 29177107
Morbidly adherent placentation is associated with increased maternal morbidity and mortality. Recently, there has been mounting evidence supporting the benefits of a standardized multidisciplinary approach at tertiary teaching hospitals. Our...
2.
Tzeng T, Schattgen S, Monks B, Wang D, Cerny A, Latz E, et al.
Cell Rep
. 2016 Jun;
16(2):571-582.
PMID: 27346360
Inflammasome activation is associated with numerous diseases. However, in vivo detection of the activated inflammasome complex has been limited by a dearth of tools. We have developed transgenic mice that...
3.
Swain C, Simon M, Monks B
Obstet Gynecol Clin North Am
. 2015 Sep;
42(3):519-32.
PMID: 26333641
The thoughtful development and implementation of a comprehensive obstetric/gynecologic (OB/GYN) hospitalist program can result in a cost-effective practice model that provides increased value through a wide variety of services. The...
4.
Haeri S, Rais S, Monks B
BMJ Case Rep
. 2015 Jan;
2015.
PMID: 25564634
Uterine inversion is a rare but life-threatening obstetrical emergency that occurs when the fundus of the uterus prolapses through the cervix, hence turning the uterus inside out. In this case...
5.
Gupta R, Ghosh S, Monks B, DeOliveira R, Tzeng T, Kalantari P, et al.
J Biol Chem
. 2014 Apr;
289(20):13701-5.
PMID: 24692555
The inflammatory cytokine IL-1β is critical for host responses against many human pathogens. Here, we define Group B Streptococcus (GBS)-mediated activation of the Nod-like receptor-P3 (NLRP3) inflammasome in macrophages. NLRP3...
6.
Carpenter S, Aiello D, Atianand M, Ricci E, Gandhi P, Hall L, et al.
Science
. 2013 Aug;
341(6147):789-92.
PMID: 23907535
An inducible program of inflammatory gene expression is central to antimicrobial defenses. This response is controlled by a collaboration involving signal-dependent activation of transcription factors, transcriptional co-regulators, and chromatin-modifying factors....
7.
Conlon J, Burdette D, Sharma S, Bhat N, Thompson M, Jiang Z, et al.
J Immunol
. 2013 Apr;
190(10):5216-25.
PMID: 23585680
Vascular disrupting agents such as 5,6-dimethylxanthenone-4-acetic acid (DMXAA) represent a novel approach for cancer treatment. DMXAA has potent antitumor activity in mice and, despite significant preclinical promise, failed human clinical...
8.
Bartok E, Bauernfeind F, Khaminets M, Jakobs C, Monks B, Fitzgerald K, et al.
Nat Methods
. 2013 Jan;
10(2):147-154.
PMID: 23291722
Measurement of protease activity in living cells or organisms remains a challenging task. We here present a transgene-encoded biosensor that reports the proteolytic activity of caspase-1 in the course of...
9.
Shaughnessy J, Ram S, Bhattacharjee A, Pedrosa J, Tran C, Horvath G, et al.
J Biol Chem
. 2011 May;
286(25):22235-42.
PMID: 21531728
Human factor H (HufH), a key inhibitor of the alternative pathway of complement, binds to Neisseria gonorrhoeae and constitutes an important mechanism of human-specific complement evasion. The C-terminal domain 20...
10.
Ngampasutadol J, Ram S, Gulati S, Agarwal S, Li C, Visintin A, et al.
J Immunol
. 2008 Feb;
180(5):3426-35.
PMID: 18292569
Complement forms a key arm of innate immune defenses against gonococcal infection. Sialylation of gonococcal lipo-oligosaccharide, or expression of porin 1A (Por1A) protein, enables Neisseria gonorrhoeae to bind the alternative...