Brian M Janelsins
Overview
Explore the profile of Brian M Janelsins including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
419
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Recent Articles
1.
Myler H, Pedras-Vasconcelos J, Phillips K, Hottenstein C, Chamberlain P, Devanaryan V, et al.
AAPS J
. 2021 Dec;
24(1):4.
PMID: 34853961
Evolving immunogenicity assay performance expectations and a lack of harmonized anti-drug antibody validation testing and reporting tools have resulted in significant time spent by health authorities and sponsors on resolving...
2.
Janelsins B, Lu M, Datta S
Proc Natl Acad Sci U S A
. 2013 Dec;
111(1):373-8.
PMID: 24344308
Interleukin (IL) 17-secreting CD4(+) helper T cells (Th17 cells) are essential for host defense at mucosal surfaces, and Th17 cell dysregulation can result in autoimmunity. Exposure to microbial products, such...
3.
Hanson M, Hixon J, Li W, Felber B, Anver M, Stewart C, et al.
Gastroenterology
. 2013 Oct;
146(1):210-221.e13.
PMID: 24120477
Background & Aims: Treatment of inflammatory bowel disease would benefit from specific targeting of therapeutics to the intestine. We developed a strategy for localized delivery of the immunosuppressive cytokine interleukin...
4.
Myles I, Fontecilla N, Janelsins B, Vithayathil P, Segre J, Datta S
J Immunol
. 2013 Aug;
191(6):3200-9.
PMID: 23935191
Mechanisms underlying modern increases in prevalence of human inflammatory diseases remain unclear. The hygiene hypothesis postulates that decreased microbial exposure has, in part, driven this immune dysregulation. However, dietary fatty...
5.
Janelsins B, Sumpter T, Tkacheva O, Rojas-Canales D, Erdos G, Mathers A, et al.
Blood
. 2013 Feb;
121(15):2923-33.
PMID: 23365459
Substance-P and hemokinin-1 are proinflammatory neuropeptides with potential to promote type 1 immunity through agonistic binding to neurokinin-1 receptor (NK1R). Dendritic cells (DCs) are professional antigen-presenting cells that initiate and...
6.
Valdez P, Vithayathil P, Janelsins B, Shaffer A, Williamson P, Datta S
Immunity
. 2012 Apr;
36(4):668-79.
PMID: 22464170
T helper 17 (Th17) cells play an important role in mucosal host defense through production of the signature cytokines IL-17 and IL-22. Prostaglandin E2 (PGE2) has been shown to enhance...
7.
Mathers A, Janelsins B, Rubin J, Tkacheva O, Shufesky W, Watkins S, et al.
J Immunol
. 2009 Jan;
182(2):921-33.
PMID: 19124735
Human skin-migratory dendritic cells (DCs) have the ability to prime and bias Th1 and Th2 CD4+ T lymphocytes. However, whether human cutaneous DCs are capable of initiating proinflammatory Th17 responses...
8.
Janelsins B, Mathers A, Tkacheva O, Erdos G, Shufesky W, Morelli A, et al.
Blood
. 2008 Nov;
113(13):3017-26.
PMID: 18987361
Dendritic cells (DCs) are the preferred targets for immunotherapy protocols focused on stimulation of cellular immune responses. However, regardless of initial promising results, ex vivo generated DCs do not always...
9.
Mathers A, Tckacheva O, Janelsins B, Shufesky W, Morelli A, Larregina A
J Immunol
. 2007 May;
178(11):7006-17.
PMID: 17513750
The proinflammatory capacities of the skin and the presence of high numbers of resident dendritic cells (DCs) constitute an ideal microenvironment for successful immunizations. Regardless of the ability of DCs...