Brian Keith
Overview
Explore the profile of Brian Keith including associated specialties, affiliations and a list of published articles.
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Articles
54
Citations
8770
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Recent Articles
1.
Keith B, Welch D, Agarwal N, Blair C, Chukwudozie I, Shevde L, et al.
Nat Cancer
. 2025 Jan;
6(2):223-225.
PMID: 39747649
No abstract available.
2.
Alexander K, Yu R, Skuli N, Coffey N, Nguyen S, Faunce C, et al.
Nat Cell Biol
. 2025 Jan;
27(2):322-335.
PMID: 39747580
Nuclear speckles are dynamic nuclear bodies characterized by high concentrations of factors involved in RNA production. Although the contents of speckles suggest multifaceted roles in gene regulation, their biological functions...
3.
Han X, Burrows M, Kim L, Xu J, Vostrejs W, Van Le T, et al.
Cell Rep
. 2024 Nov;
43(11):114972.
PMID: 39535921
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with abundant cancer-associated fibroblasts (CAFs) creating hallmark desmoplasia that limits oxygen and nutrient delivery. This study explores the importance of lipid homeostasis...
4.
Skuli N, Majmundar A, Krock B, Mesquita R, Mathew L, Quinn Z, et al.
J Clin Invest
. 2024 Apr;
134(8).
PMID: 38618964
No abstract available.
5.
Riscal R, Gardner S, Coffey N, Carens M, Mesaros C, Xu J, et al.
Cancer Res
. 2024 Feb;
84(10):1570-1582.
PMID: 38417134
Significance: The bile acid biosynthetic enzyme HSD3B7 is essential for ccRCC cell survival and can be targeted to induce accumulation of cholesterol-derived oxysterols and apoptotic cell death.
6.
Li F, Liu P, Mi W, Li L, Anderson N, Lesner N, et al.
Nat Cancer
. 2024 Jan;
5(1):131-146.
PMID: 38168934
Availability of the essential amino acid methionine affects cellular metabolism and growth, and dietary methionine restriction has been implicated as a cancer therapeutic strategy. Nevertheless, how liver cancer cells respond...
7.
Alexander K, Yu R, Skuli N, Coffey N, Nguyen S, Faunce C, et al.
bioRxiv
. 2023 Sep;
PMID: 37745397
Nuclear speckles are membrane-less bodies within the cell nucleus enriched in RNA biogenesis, processing, and export factors. In this study we investigated speckle phenotype variation in human cancer, finding a...
8.
Khare S, Kim L, Lobel G, Doulias P, Ischiropoulos H, Nissim I, et al.
Cancer Metab
. 2021 Dec;
9(1):40.
PMID: 34861885
Background: Kidney cancer is a common adult malignancy in the USA. Clear cell renal cell carcinoma (ccRCC), the predominant subtype of kidney cancer, is characterized by widespread metabolic changes. Urea...
9.
Riscal R, Bull C, Mesaros C, Finan J, Carens M, Ho E, et al.
Cancer Discov
. 2021 Jul;
11(12):3106-3125.
PMID: 34244212
Significance: We demonstrate that ccRCC cells are auxotrophic for exogenous cholesterol to maintain PI3K/AKT signaling pathway and ROS homeostasis. Blocking cholesterol import through the HDL transporter SCARB1 compromises ccRCC cell...
10.
Huangyang P, Li F, Lee P, Nissim I, Weljie A, Mancuso A, et al.
Cell Metab
. 2020 May;
31(5):1032.
PMID: 32375058
No abstract available.