Brian F Kiesel
Overview
Explore the profile of Brian F Kiesel including associated specialties, affiliations and a list of published articles.
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Articles
28
Citations
351
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Recent Articles
1.
Deppas J, Kiesel B, Guo J, Parise R, Clump D, DArgenio D, et al.
Cancer Chemother Pharmacol
. 2024 May;
94(2):271-283.
PMID: 38743253
Background: The Ataxia Telangiectasia and Rad3-related (ATR) protein complex is an apical initiator of DNA damage response pathways. Several ATR inhibitors (ATRi) are in clinical development including berzosertib (formerly M6620,...
2.
Malhotra M, Pahuja S, Kiesel B, Appleman L, Ding F, Lin Y, et al.
Breast Cancer Res Treat
. 2023 Feb;
198(3):487-498.
PMID: 36853577
Background: Veliparib is a poly-ADP-ribose polymerase (PARP) inhibitor, and it has clinical activity with every 3 weeks carboplatin and paclitaxel. In breast cancer, weekly paclitaxel is associated with improved overall...
3.
Kiesel B, Parise R, Krishnamurthy A, Gore S, Beumer J
Biomed Chromatogr
. 2022 Jul;
36(11):e5455.
PMID: 35876841
Ataxia-telangiectasia-mutated and Rad3-related (ATR) is master regulator of the DNA-damage response that, through multiple mechanisms, can promote cancer cell survival in response to replication stress from sources, including chemotherapy and...
4.
Kiesel B, Deppas J, Guo J, Parise R, Clump D, Bakkenist C, et al.
Cancer Chemother Pharmacol
. 2022 May;
89(6):795-807.
PMID: 35507041
Purpose: Ataxia Telangiectasia and Rad3-related (ATR) is a pivotal component of the DNA damage response and repair pathways that is activated in responses to cytotoxic cancer treatments. Several ATR inhibitors...
5.
Manzo J, Puhalla S, Pahuja S, Ding F, Lin Y, Appleman L, et al.
Cancer Chemother Pharmacol
. 2022 Apr;
89(5):721-735.
PMID: 35435472
Purpose: BRCA1 or BRCA2 mutated cancers (BRCAmut) have intrinsic sensitivity to PARP inhibitors due to deficiency in homologous recombination-mediated DNA repair. There are similarities between BRCAmut and BRCAwt ovarian and...
6.
Kiesel B, Guo J, Parise R, Venkataramanan R, Clump D, Bakkenist C, et al.
Cancer Chemother Pharmacol
. 2022 Jan;
89(2):231-242.
PMID: 35066692
Purpose: Ataxia telangiectasia and Rad3-related (ATR) initiates and regulates cellular responses to DNA damage, such as those caused by cancer treatments. Several ATR inhibitors (ATRi) are in clinical development including...
7.
Tan A, Chan N, Kiesel B, Stein M, Moss R, Malhotra J, et al.
Cancer Chemother Pharmacol
. 2021 Oct;
89(1):49-58.
PMID: 34669023
Purpose: Veliparib (V), an oral poly(ADP-ribose) polymerase (PARP) inhibitor, potentiates effects of alkylating agents and topoisomerase inhibitors in preclinical tumor models. We conducted a phase I trial of V with...
8.
Jacobs S, Lee J, George T, Wade 3rd J, Stella P, Wang D, et al.
Clin Cancer Res
. 2020 Nov;
27(6):1612-1622.
PMID: 33203645
Purpose: In metastatic colorectal cancer (mCRC), () gene amplification is implicated in anti-EGFR therapy resistance. We sought to determine the recommended phase II dose (RP2D) and efficacy of neratinib, a...
9.
Joshi A, Kiesel B, Chaphekar N, Jones R, Guo J, Kunos C, et al.
Cancer Chemother Pharmacol
. 2020 Sep;
86(5):633-640.
PMID: 32989483
Purpose: To investigate the metabolic pathways of triapine in primary cultures of human hepatocytes and human hepatic subcellular fractions; to investigate interactions of triapine with tenofovir and emtricitabine; and to...
10.
Holleran J, Parise R, Guo J, Kiesel B, Taylor S, Ivy S, et al.
J Pharm Biomed Anal
. 2020 Jul;
189:113464.
PMID: 32659569
We developed a high-performance liquid chromatography mass spectrometry method for quantitating iohexol in 50 μL human plasma. After acetonitrile protein precipitation, chromatographic separation was achieved with a Shodex Asahipak NH2P-50...