Brian Everatt
Overview
Explore the profile of Brian Everatt including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
25
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0
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Recent Articles
1.
Grand D, Gosling M, Baettig U, Bahra P, Bala K, Brocklehurst C, et al.
J Med Chem
. 2021 May;
64(11):7241-7260.
PMID: 34028270
Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) ion channel are established as the primary causative factor in the devastating lung disease cystic fibrosis (CF). More recently, cigarette smoke...
2.
Sandham D, Arnold N, Aschauer H, Bala K, Barker L, Brown L, et al.
Bioorg Med Chem
. 2013 Sep;
21(21):6582-91.
PMID: 24021582
Optimization of a 7-azaindole-3-acetic acid CRTh2 receptor antagonist chemotype derived from high throughput screening furnished a highly selective compound NVP-QAV680 with low nM functional potency for inhibition of CRTh2 driven...
3.
Jiang Z, Reilly J, Everatt B, Briard E
J Pharm Biomed Anal
. 2010 Dec;
54(4):722-9.
PMID: 21126842
High non-specific binding (NSB) is one of the most common reasons for candidate failure in potential positron emission tomography (PET) radiotracer development. It is of interest to develop high throughput...
4.
Jiang Z, Reilly J, Everatt B, Smith N
J Chromatogr A
. 2009 Jan;
1216(12):2439-48.
PMID: 19178914
A novel porous zwitterionic monolith was prepared by thermal co-polymerisation of 2-methacryloyloxyethyl phosphorylcholine (MPC) and ethylene glycol dimethacrylate (EDMA) within 100 microm I.D. capillaries. Mercury intrusion porosimetry, scanning electron microscopy...
5.
Jiang Z, Reilly J, Everatt B
Electrophoresis
. 2008 Sep;
29(17):3674-84.
PMID: 18803182
Lung tissue distribution of an inhaled drug is important for its potency in the airways and with minimum systemic effects within its dose range. As the lung has the smallest...
6.
Sandham D, Aldcroft C, Baettig U, Barker L, Beer D, Bhalay G, et al.
Bioorg Med Chem Lett
. 2007 May;
17(15):4347-50.
PMID: 17531480
High throughput screening identified a phenoxyacetic acid scaffold as a novel CRTh2 receptor antagonist chemotype, which could be optimised to furnish a compound with functional potency for inhibition of human...