Brian Coventry
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Explore the profile of Brian Coventry including associated specialties, affiliations and a list of published articles.
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28
Citations
1054
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Recent Articles
21.
Gerben S, Borst A, Hicks D, Moczygemba I, Feldman D, Coventry B, et al.
Biochemistry
. 2023 Jan;
62(2):358-368.
PMID: 36627259
A challenge for design of protein-small-molecule recognition is that incorporation of cavities with size, shape, and composition suitable for specific recognition can considerably destabilize protein monomers. This challenge can be...
22.
Hicks D, Kennedy M, Thompson K, DeWitt M, Coventry B, Kang A, et al.
Proc Natl Acad Sci U S A
. 2022 Jul;
119(30):e2113400119.
PMID: 35862457
Function follows form in biology, and the binding of small molecules requires proteins with pockets that match the shape of the ligand. For design of binding to symmetric ligands, protein...
23.
Cao L, Coventry B, Goreshnik I, Huang B, Sheffler W, Park J, et al.
Nature
. 2022 Mar;
605(7910):551-560.
PMID: 35332283
The design of proteins that bind to a specific site on the surface of a target protein using no information other than the three-dimensional structure of the target remains a...
24.
Jeong B, Cha J, Hwang I, Kim U, Adolf-Bryfogle J, Coventry B, et al.
MAbs
. 2022 Jan;
14(1):2021601.
PMID: 35030983
Coronavirus disease 2019, caused by SARS-CoV-2, remains an on-going pandemic, partly due to the emergence of variant viruses that can "break-through" the protection of the current vaccines and neutralizing antibodies...
25.
Coventry B, Baker D
PLoS Comput Biol
. 2021 Mar;
17(3):e1008061.
PMID: 33684097
In aqueous solution, polar groups make hydrogen bonds with water, and hence burial of such groups in the interior of a protein is unfavorable unless the loss of hydrogen bonds...
26.
Maguire J, Haddox H, Strickland D, Halabiya S, Coventry B, Griffin J, et al.
Proteins
. 2020 Nov;
89(4):436-449.
PMID: 33249652
The FastDesign protocol in the molecular modeling program Rosetta iterates between sequence optimization and structure refinement to stabilize de novo designed protein structures and complexes. FastDesign has been used previously...
27.
Cao L, Goreshnik I, Coventry B, Case J, Miller L, Kozodoy L, et al.
Science
. 2020 Sep;
370(6515):426-431.
PMID: 32907861
Targeting the interaction between the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein and the human angiotensin-converting enzyme 2 (ACE2) receptor is a promising therapeutic strategy. We designed inhibitors...
28.
Cao L, Goreshnik I, Coventry B, Case J, Miller L, Kozodoy L, et al.
bioRxiv
. 2020 Aug;
PMID: 32793905
We used two approaches to design proteins with shape and chemical complementarity to the receptor binding domain (RBD) of SARS-CoV-2 Spike protein near the binding site for the human ACE2...
29.
Leman J, Weitzner B, Lewis S, Adolf-Bryfogle J, Alam N, Alford R, et al.
Nat Methods
. 2020 Jun;
17(7):665-680.
PMID: 32483333
The Rosetta software for macromolecular modeling, docking and design is extensively used in laboratories worldwide. During two decades of development by a community of laboratories at more than 60 institutions,...