Brian Coventry
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Explore the profile of Brian Coventry including associated specialties, affiliations and a list of published articles.
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28
Citations
1054
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Recent Articles
11.
Adams C, Kim H, Burtner A, Lee D, Dobbins C, Criswell C, et al.
bioRxiv
. 2024 Apr;
PMID: 38659926
Toll-like Receptor 3 (TLR3) is a pattern recognition receptor that initiates antiviral immune responses upon binding double-stranded RNA (dsRNA). Several nucleic acid-based TLR3 agonists have been explored clinically as vaccine...
12.
Huddy T, Hsia Y, Kibler R, Xu J, Bethel N, Nagarajan D, et al.
Nature
. 2024 Mar;
627(8005):898-904.
PMID: 38480887
A wooden house frame consists of many different lumber pieces, but because of the regularity of these building blocks, the structure can be designed using straightforward geometrical principles. The design...
13.
An L, Said M, Tran L, Majumder S, Goreshnik I, Lee G, et al.
bioRxiv
. 2024 Jan;
PMID: 38187589
A general method for designing proteins to bind and sense any small molecule of interest would be widely useful. Due to the small number of atoms to interact with, binding...
14.
Lee G, Pellock S, Norn C, Tischer D, Dauparas J, Anischenko I, et al.
bioRxiv
. 2023 Nov;
PMID: 37961294
Despite transformative advances in protein design with deep learning, the design of small-molecule-binding proteins and sensors for arbitrary ligands remains a grand challenge. Here we combine deep learning and physics-based...
15.
Glasscock C, Pecoraro R, McHugh R, Doyle L, Chen W, Boivin O, et al.
bioRxiv
. 2023 Oct;
PMID: 37790440
Sequence-specific DNA-binding proteins (DBPs) play critical roles in biology and biotechnology, and there has been considerable interest in the engineering of DBPs with new or altered specificities for genome editing...
16.
Huang B, Abedi M, Ahn G, Coventry B, Sappington I, Wang R, et al.
bioRxiv
. 2023 Oct;
PMID: 37781607
Endocytosis and lysosomal trafficking of cell surface receptors can be triggered by interaction with endogenous ligands. Therapeutic approaches such as LYTAC and KineTAC, have taken advantage of this to target...
17.
Huddy T, Hsia Y, Kibler R, Xu J, Bethel N, Nagarajan D, et al.
bioRxiv
. 2023 Jun;
PMID: 37333359
A wooden house frame consists of many different lumber pieces, but because of the regularity of these building blocks, the structure can be designed using straightforward geometrical principles. The design...
18.
Bennett N, Coventry B, Goreshnik I, Huang B, Allen A, Vafeados D, et al.
Nat Commun
. 2023 May;
14(1):2625.
PMID: 37149653
Recently it has become possible to de novo design high affinity protein binding proteins from target structural information alone. There is, however, considerable room for improvement as the overall design...
19.
Edman N, Redler R, Phal A, Schlichthaerle T, Srivatsan S, Etemadi A, et al.
bioRxiv
. 2023 Mar;
PMID: 36993355
Growth factors and cytokines signal by binding to the extracellular domains of their receptors and drive association and transphosphorylation of the receptor intracellular tyrosine kinase domains, initiating downstream signaling cascades....
20.
Yeh A, Norn C, Kipnis Y, Tischer D, Pellock S, Evans D, et al.
Nature
. 2023 Feb;
614(7949):774-780.
PMID: 36813896
De novo enzyme design has sought to introduce active sites and substrate-binding pockets that are predicted to catalyse a reaction of interest into geometrically compatible native scaffolds, but has been...