Brian Coventry
Overview
Explore the profile of Brian Coventry including associated specialties, affiliations and a list of published articles.
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28
Citations
1054
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Recent Articles
1.
Adams C, Kim H, Burtner A, Lee D, Dobbins C, Criswell C, et al.
Nat Commun
. 2025 Jan;
16(1):1234.
PMID: 39890776
Toll-like Receptor 3 (TLR3) is a pattern recognition receptor that initiates antiviral immune responses upon binding double-stranded RNA (dsRNA). Several nucleic acid-based TLR3 agonists have been explored clinically as vaccine...
2.
Glogl M, Krishnakumar A, Ragotte R, Goreshnik I, Coventry B, Bera A, et al.
Science
. 2024 Dec;
386(6726):1154-1161.
PMID: 39636970
Despite progress in designing protein-binding proteins, the shape matching of designs to targets is lower than in many native protein complexes, and design efforts have failed for the tumor necrosis...
3.
Ragotte R, Tortorici M, Catanzaro N, Addetia A, Coventry B, Froggatt H, et al.
bioRxiv
. 2024 Nov;
PMID: 39574666
Middle-East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic pathogen with 36% case-fatality rate in humans. No vaccines or specific therapeutics are currently approved to use in humans or the camel...
4.
Huang B, Abedi M, Ahn G, Coventry B, Sappington I, Tang C, et al.
Nature
. 2024 Sep;
638(8051):796-804.
PMID: 39322662
Endocytosis and lysosomal trafficking of cell surface receptors can be triggered by endogenous ligands. Therapeutic approaches such as lysosome-targeting chimaeras (LYTACs) and cytokine receptor-targeting chimeras (KineTACs) have used this to...
5.
Huang B, Coventry B, Borowska M, Arhontoulis D, Exposit M, Abedi M, et al.
Nat Commun
. 2024 Aug;
15(1):7064.
PMID: 39152100
Cytokine release syndrome (CRS), commonly known as cytokine storm, is an acute systemic inflammatory response that is a significant global health threat. Interleukin-6 (IL-6) and interleukin-1 (IL-1) are key pro-inflammatory...
6.
Sun K, Li S, Zheng B, Zhu Y, Wang T, Liang M, et al.
Cell Res
. 2024 Aug;
34(12):846-858.
PMID: 39143121
Abiotic D-proteins that selectively bind to natural L-proteins have gained significant biotechnological interest. However, the underlying structural principles governing such heterochiral protein-protein interactions remain largely unknown. In this study, we...
7.
Wu K, Jiang H, Hicks D, Liu C, Muratspahic E, Ramelot T, et al.
bioRxiv
. 2024 Jul;
PMID: 39071356
Intrinsically disordered proteins and peptides play key roles in biology, but the lack of defined structures and the high variability in sequence and conformational preferences has made targeting such systems...
8.
Liu C, Wu K, Choi H, Han H, Zhang X, Watson J, et al.
bioRxiv
. 2024 Jul;
PMID: 39071267
Proteins which bind intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) with high affinity and specificity could have considerable utility for therapeutic and diagnostic applications. However, a general methodology...
9.
An L, Said M, Tran L, Majumder S, Goreshnik I, Lee G, et al.
Science
. 2024 Jul;
385(6706):276-282.
PMID: 39024436
We describe an approach for designing high-affinity small molecule-binding proteins poised for downstream sensing. We use deep learning-generated pseudocycles with repeating structural units surrounding central binding pockets with widely varying...
10.
Edman N, Phal A, Redler R, Schlichthaerle T, Srivatsan S, Ehnes D, et al.
Cell
. 2024 Jun;
187(14):3726-3740.e43.
PMID: 38861993
Many growth factors and cytokines signal by binding to the extracellular domains of their receptors and driving association and transphosphorylation of the receptor intracellular tyrosine kinase domains, initiating downstream signaling...