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Brian Cicali

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Articles 23
Citations 174
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Recent Articles
1.
Chun D, Mehta P, Guzy S, Cicali B, Lauretti G, Lanchote V, et al.
CPT Pharmacometrics Syst Pharmacol . 2025 Feb; PMID: 39959991
Neuropathic pain, often associated with diabetic neuropathy or nerve compression injuries, arises from damage or dysfunction in the somatosensory nervous system. Tramadol, frequently prescribed for this pain, has its fraction...
2.
Jayachandran P, Knochel J, Cicali B, Rowland Yeo K
CPT Pharmacometrics Syst Pharmacol . 2024 Nov; 13(11):1815-1819. PMID: 39552441
No abstract available.
3.
Chen H, Chun D, Lingineni K, Guzy S, Cristofoletti R, Hoechel J, et al.
CPT Pharmacometrics Syst Pharmacol . 2024 Nov; 13(11):2016-2025. PMID: 39551952
Breakthrough bleeding (BTB) is a common side effect of hormonal contraception and is thought to impact adherence to combined oral contraceptives (COCs) but respective dose-response relationships are not yet fully...
4.
Yin X, Cicali B, Rodriguez-Vera L, Lukacova V, Cristofoletti R, Schmidt S
Pharmaceutics . 2024 Jun; 16(6). PMID: 38931859
Carbamazepine (CBZ) is commonly prescribed for epilepsy and frequently used in polypharmacy. However, concerns arise regarding its ability to induce the metabolism of other drugs, including itself, potentially leading to...
5.
Rodriguez-Vera L, Yin X, Almoslem M, Romahn K, Cicali B, Lukacova V, et al.
Pharmaceutics . 2023 Oct; 15(10). PMID: 37896246
Regulatory agencies worldwide expect that clinical pharmacokinetic drug-drug interactions (DDIs) between an investigational new drug and other drugs should be conducted during drug development as part of an adequate assessment...
6.
Schmidt S, Vozmediano V, Cristofoletti R, Kim S, Lin Z, De Moraes N, et al.
CPT Pharmacometrics Syst Pharmacol . 2023 Jul; 12(7):883-888. PMID: 37452453
No abstract available.
7.
Kim S, Cicali B, Pressly M, da Silva L, Wendl T, Vozmediano V, et al.
Pharmaceutics . 2023 May; 15(5). PMID: 37242635
Levonorgestrel (LNG) is a progestin used in many contraceptive formulations, including subcutaneous implants. There is an unmet need for developing long-acting formulations for LNG. To develop long-acting formulations, release functions...
8.
Cicali B, da Silva L, Sarayani A, Lingineni K, Pressly M, Kim S, et al.
Clin Pharmacol Ther . 2022 Jun; 112(4):909-916. PMID: 35723889
Worldwide, 922 million women of reproductive age (or their partners) use some sort of contraception to prevent pregnancy. Oral combined hormonal contraceptives (CHCs) typically utilize a combination of a progestin...
9.
Cicali B, Schmidt S, Zeitlinger M, Brown J
Pharmaceutics . 2022 Apr; 14(4). PMID: 35456537
Macrolide antibiotics have received criticism concerning their use and risk of treatment failure. Nevertheless, they are an important class of antibiotics and are frequently used in clinical practice for treating...
10.
Michaud V, Bikmetov R, Smith M, Dow P, Darakjian L, Deodhar M, et al.
J Pers Med . 2021 Nov; 11(11). PMID: 34834526
Cytochrome P450 2D6 (CYP2D6) activity is highly variable due to several factors, including genetic polymorphisms and drug-drug-gene interactions. Hydrocodone, oxycodone, codeine, and tramadol the most commonly prescribed CYP2D6-activated opioids for...