Damien B Wilburn
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Explore the profile of Damien B Wilburn including associated specialties, affiliations and a list of published articles.
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24
Citations
238
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Recent Articles
1.
Sidharthan V, Sibley C, Dunne-Dombrink K, Yang M, Zahurancik W, Balaratnam S, et al.
Nucleic Acids Res
. 2024 Dec;
53(1.
PMID: 39676671
Despite interest in developing therapeutics that leverage binding pockets in structured RNAs-whose dysregulation leads to diseases-such drug discovery efforts are limited. Here, we have used a small molecule microarray (SMM)...
2.
Edgington R, Wilburn D
J Am Soc Mass Spectrom
. 2024 Sep;
35(12):2849-2858.
PMID: 39332818
Ubiquitylation is a structurally and functionally diverse post-translational modification that involves the covalent attachment of the small protein ubiquitin to other protein substrates. Trypsin-based proteomics is the most common approach...
3.
DeBruin J, Wilburn D, Feldhoff R, Staub N
PLoS One
. 2023 Aug;
18(8):e0289296.
PMID: 37527281
Plethodontid salamanders are well known for their distinct courtship rituals and the associated pheromonal signaling. However, little is known about pheromones produced in the lone Asian plethodontid species Karsenia koreana....
4.
Witus S, Tuttle L, Li W, Zelter A, Wang M, Kermoade K, et al.
EMBO J
. 2023 Jun;
42(15):e113565.
PMID: 37305927
BRCA1/BARD1 is a tumor suppressor E3 ubiquitin (Ub) ligase with roles in DNA damage repair and in transcriptional regulation. BRCA1/BARD1 RING domains interact with nucleosomes to facilitate mono-ubiquitylation of distinct...
5.
Rivera A, Wilburn D, Swanson W
Mol Biol Evol
. 2022 May;
39(5).
PMID: 35587583
The rapid evolution of fertilization proteins has generated remarkable diversity in molecular structure and function. Glycoproteins of vertebrate egg coats contain multiple zona pellucida (ZP)-N domains (1-6 copies) that facilitate...
6.
Wilburn D, Kunkel C, Feldhoff R, Feldhoff P, Searle B
Front Cell Dev Biol
. 2022 Mar;
10:828947.
PMID: 35281090
Reproductive proteins evolve at unparalleled rates, resulting in tremendous diversity of both molecular composition and biochemical function between gametes of different taxonomic clades. To date, the proteomic composition of amphibian...
7.
Richards A, Chen K, Wilburn D, Stevenson E, Polacco B, Searle B, et al.
J Proteome Res
. 2022 Mar;
21(4):1124-1136.
PMID: 35234472
The use of multiple proteases has been shown to increase protein sequence coverage in proteomics experiments; however, due to the additional analysis time required, it has not been widely adopted...
8.
Killingbeck E, Wilburn D, Merrihew G, MacCoss M, Swanson W
Mol Reprod Dev
. 2021 Jun;
88(7):500-515.
PMID: 34148267
Ancestrally marine threespine stickleback fish (Gasterosteus aculeatus) have undergone an adaptive radiation into freshwater environments throughout the Northern Hemisphere, creating an excellent model system for studying molecular adaptation and speciation....
9.
Tuttle L, Pacheco D, Warfield L, Wilburn D, Hahn S, Klevit R
Nat Commun
. 2021 Apr;
12(1):2220.
PMID: 33850123
The acidic activation domain (AD) of yeast transcription factor Gal4 plays a dual role in transcription repression and activation through binding to Gal80 repressor and Mediator subunit Med15. The activation...
10.
Wilburn D, Richards A, Swaney D, Searle B
J Proteome Res
. 2021 Mar;
20(4):1951-1965.
PMID: 33729787
Library searching is a powerful technique for detecting peptides using either data independent or data dependent acquisition. While both large-scale spectrum library curators and deep learning prediction approaches have focused...