Brian C DeFelice
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Explore the profile of Brian C DeFelice including associated specialties, affiliations and a list of published articles.
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27
Citations
537
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Recent Articles
1.
Goldman D, Xue K, Parrott A, Lopez J, Vila J, Jeeda R, et al.
Proc Natl Acad Sci U S A
. 2025 Mar;
122(11):e2322440122.
PMID: 40063808
The long-term success of introduced populations depends on both their initial size and ability to compete against existing residents, but it remains unclear how these factors collectively shape colonization dynamics....
2.
Hein M, Peng D, Todorova V, McCarthy F, Kim K, Liu C, et al.
Cell
. 2025 Jan;
188(4):1137-1155.e20.
PMID: 39742809
Defining the subcellular distribution of all human proteins and their remodeling across cellular states remains a central goal in cell biology. Here, we present a high-resolution strategy to map subcellular...
3.
Sandhu W, Gray I, Lin S, Elias J, DeFelice B
Anal Chem
. 2024 Oct;
96(44):17465-17470.
PMID: 39454023
Consistently collecting high-quality liquid chromatography-coupled tandem mass spectrometry (LC-MS/MS) data is a time-consuming hurdle for untargeted workflows. Analytical controls such as internal and biological standards are commonly included in high-throughput...
4.
Vorperian S, DeFelice B, Buonomo J, Chinchinian H, Gray I, Yan J, et al.
Clin Chem
. 2024 Oct;
70(11):1344-1354.
PMID: 39383112
Background: Early detection of the cell type changes underlying several genitourinary tract diseases largely remains an unmet clinical need, where existing assays, if available, lack the cellular resolution afforded by...
5.
Ho P, Nguyen T, Sanchez J, DeFelice B, Huang K
Nat Microbiol
. 2024 Mar;
9(4):1036-1048.
PMID: 38486074
Microbial community dynamics arise through interspecies interactions, including resource competition, cross-feeding and pH modulation. The individual contributions of these mechanisms to community structure are challenging to untangle. Here we develop...
6.
Vorperian S, DeFelice B, Buonomo J, Chinchinian H, Gray I, Yan J, et al.
bioRxiv
. 2023 Nov;
PMID: 37961398
Urine is assayed alongside blood in medicine, yet current clinical diagnostic tests utilize only a small fraction of its total biomolecular repertoire, potentially foregoing high-resolution insights into human health and...
7.
Tsusaka T, Oses-Prieto J, Lee C, DeFelice B, Burlingame A, Goldberg E
iScience
. 2023 Jul;
26(7):107235.
PMID: 37485368
Ketone bodies are short-chain fatty acids produced in the liver during periods of limited glucose availability that provide an alternative energy source for the brain, heart, and skeletal muscle. Beyond...
8.
Noecker C, Sanchez J, Bisanz J, Escalante V, Alexander M, Trepka K, et al.
PLoS Biol
. 2023 May;
21(5):e3002125.
PMID: 37205710
Human gut bacteria perform diverse metabolic functions with consequences for host health. The prevalent and disease-linked Actinobacterium Eggerthella lenta performs several unusual chemical transformations, but it does not metabolize sugars...
9.
Tsusaka T, Oses-Prieto J, Lee C, DeFelice B, Burlingame A, Goldberg E
bioRxiv
. 2023 Apr;
PMID: 37090555
Ketone bodies are short chain fatty acids produced in the liver during periods of limited glucose availability that provide an alternative source of energy for the brain, heart, and skeletal...
10.
Spring J, Beilinson V, DeFelice B, Sanchez J, Fischbach M, Chervonsky A, et al.
Viruses
. 2023 Feb;
15(2).
PMID: 36851600
Both viruses and bacteria produce "pathogen associated molecular patterns" that may affect microbial pathogenesis and anti-microbial responses. Additionally, bacteria produce metabolites, while viruses could change the metabolic profiles of the...