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Randi K Johnson

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Citations 401
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Recent Articles
1.
Slack S, Esquinca E, Arehart C, Boorgula M, Szczesny B, Romero A, et al.
medRxiv . 2025 Feb; PMID: 39974046
Background: Genetic control of gene expression in asthma-related tissues is not well-characterized, particularly for African-ancestry populations, limiting advancement in our understanding of the increased prevalence and severity of asthma in...
2.
Francis E, Kechris K, Johnson R, Rawal S, Pathmasiri W, Rushing B, et al.
Int J Mol Sci . 2024 Jul; 25(14). PMID: 39062861
Maternal metabolism during pregnancy shapes offspring health via in utero programming. In the Healthy Start study, we identified five subgroups of pregnant women based on conventional metabolic biomarkers: Reference (...
3.
Carry P, Vanderlinden L, Johnson R, Buckner T, Steck A, Kechris K, et al.
Front Immunol . 2024 Jun; 15:1345494. PMID: 38915393
Background: Type 1 diabetes (T1D) is preceded by a heterogenous pre-clinical phase, islet autoimmunity (IA). We aimed to identify pre vs. post-IA seroconversion (SV) changes in DNAm that differed across...
4.
Szczesny B, Boorgula M, Chavan S, Campbell M, Johnson R, Kammers K, et al.
Nat Commun . 2024 May; 15(1):4546. PMID: 38806494
Asthma has striking disparities across ancestral groups, but the molecular underpinning of these differences is poorly understood and minimally studied. A goal of the Consortium on Asthma among African-ancestry Populations...
5.
Johnson R, Ireton A, Carry P, Vanderlinden L, Dong F, Romero A, et al.
Pediatr Diabetes . 2024 May; 2023. PMID: 38765731
Given the differential risk of type 1 diabetes (T1D) in offspring of affected fathers versus affected mothers and our observation that T1D cases have differential DNA methylation near the imprinted...
6.
Felton J, Redondo M, Oram R, Speake C, Long S, Onengut-Gumuscu S, et al.
Commun Med (Lond) . 2024 Apr; 4(1):66. PMID: 38582818
Background: Islet autoantibodies form the foundation for type 1 diabetes (T1D) diagnosis and staging, but heterogeneity exists in T1D development and presentation. We hypothesized that autoantibodies can identify heterogeneity before,...
7.
Tobias D, Merino J, Ahmad A, Aiken C, Benham J, Bodhini D, et al.
Nat Med . 2023 Oct; 29(10):2438-2457. PMID: 37794253
Precision medicine is part of the logical evolution of contemporary evidence-based medicine that seeks to reduce errors and optimize outcomes when making medical decisions and health recommendations. Diabetes affects hundreds...
8.
Felton J, Griffin K, Oram R, Speake C, Long S, Onengut-Gumuscu S, et al.
Commun Med (Lond) . 2023 Oct; 3(1):130. PMID: 37794169
Background: Type 1 diabetes (T1D) results from immune-mediated destruction of insulin-producing beta cells. Prevention efforts have focused on immune modulation and supporting beta cell health before or around diagnosis; however,...
9.
Felton J, Griffin K, Oram R, Speake C, Long S, Onengut-Gumuscu S, et al.
medRxiv . 2023 May; PMID: 37131690
Background: Type 1 diabetes (T1D) results from immune-mediated destruction of insulin-producing beta cells. Efforts to prevent T1D have focused on modulating immune responses and supporting beta cell health; however, heterogeneity...
10.
Buckner T, Johnson R, Vanderlinden L, Carry P, Romero A, Onengut-Gumuscu S, et al.
Front Nutr . 2023 Apr; 10:1040993. PMID: 37057071
Background: Oxylipins are inflammatory biomarkers derived from omega-3 and-6 fatty acids implicated in inflammatory diseases but have not been studied in a genome-wide association study (GWAS). The aim of this...